Abstract
We report a gene amplification of 25-hydroxyvitamin D31, α-hydroxylase and the appearance of various splice variants in glioblastoma multiforme. Some protein products of the widespread expressed variants may exert a biological function. The analysis of amplification and overexpression of alternative transcripts will provide new insights in the regulation of the 25-hydroxyvitamin D31, α-hydroxylase expression and may have implications for prognosis in glioblastoma.
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© 2003 Springer-Verlag Berlin Heidelberg
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Diesel, B., Fischer, U., Meese, E. (2003). Gene Amplification and Splice Variants of 25-Hydroxyvitamin D31, α-Hydroxylase (CYP27B1) in Glioblastoma Multiforme— A Possible Role in Tumor Progression?. In: Reichrath, J., Tilgen, W., Friedrich, M. (eds) Vitamin D Analogs in Cancer Prevention and Therapy. Recent Results in Cancer Research, vol 164. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55580-0_11
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DOI: https://doi.org/10.1007/978-3-642-55580-0_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-62435-3
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