Coronary heart disease continues to be an infrequent disease in premenopausal women, even in women with diabetes mellitus; however, after menopause (the time when estrogen production decreases) the prevalence of coronary heart disease in women increases with increasing age and reaches that of men by age 75 years. Women with premature menopause (<35 years of age) regardless of etiology (either natural or after ovariectomy) have a twofold higher risk of coronary heart disease (Wenger et al. 1993). These findings led to the conclusion that estrogens are cardioprotective and play a major role for the low prevalence of cardiovascular disease in pre-menopausal women; however, the role of estrogen (and other hormones) in the pathogenesis of coronary heart disease is still under investigation.
KeywordsCoronary Heart Disease Estrogen Replacement Therapy Coronary Heart Disease Event Medroxyprogesterone Acetate Secondary Prevention Trial
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- Bush TL (1991) Long-term effect of estrogen use on cardiovascular death in women. AHA Meeting, November 1991, Orlando/FLGoogle Scholar
- Fleming KC (1999) Hormone replacement therapy: practical prescribing. In: Charney P (ed) Coronary artery disease in women. American College of Physicians, Philadelphia, p 294Google Scholar
- Grodstein F, Stampfer MJ, Manson JE et al. (1996b) Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med 332:1589Google Scholar
- Grodstein F, Manson JE, Stampfer MJ et al. (1999) Postmenopausal hormones and recurrence of coronary events in the Nurses’ Health Study (abstract). Circulation 100: I-871Google Scholar
- Herrington DM (2001) What about estrogens now? Curr J Rev 10 (2)]Google Scholar
- Lobo RA: Hormones, hormone replacement therapy, and heart disease. In Douglas PS (ed): Cardiovascular Health and Disease in Women. Philadelphia, WB Saunders, 1993, p 153Google Scholar
- Miller BA, Ries LAG, Hankey BF et al. (eds) (1992) Cancer Statistics Review: 1973–89. National Cancer Institute,Washington DC, NIH pub no 92, p 2789Google Scholar
- Newton KM (1995) Estrogen replacement therapy and prognosis after first myocardial infarction [Abstract]. AHA Meeting, November 1995, San Diego/CAGoogle Scholar
- Pamela S, Douglas PS (2001) Coronary artery disease in women. In: Braunwald E, Zipes DP, Libby P (eds) Heart disease. Saunders, PhiladelphiaGoogle Scholar
- Sullivan JM, El-Zeky F, Vander Zwaag R, Ramanathan KK (1995) Estrogen replacement therapy after coronary artery bypass surgery: Effect on survival. Circulation 345:669Google Scholar
- WHI (Women’s Health Initiative) HRT Update. Available at: http://www.nhlbi.nih.gov/whi/HRTUpdate2001.pdf