Pathophysiology of Coronary Heart Disease and the Effects of Estrogen

  • Elisabeth von der Lohe


Atherosclerosis of the coronary arteries is the underlying pathophysiological mechanism of coronary heart disease (CHD) and is the same for both genders. There are numerous different theories with regard to the genesis of atherosclerosis. The most commonly held and most credible theory is the “response-to-injury” hypothesis by R. Ross according to which various types of injuries in the endothelium and in vascular smooth muscle cells (SMCs) lead to an exaggerated inflammatory fibroproliferative reaction in the vessel wall with subsequent plaque formation.


Coronary Heart Disease Plaque Rupture Atherosclerotic Coronary Artery Fibrinolytic Potential Coronary Vascular Smooth Muscle 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Elisabeth von der Lohe
    • 1
  1. 1.Wishard Health Services, Krannert Institute of CardiologyIndiana University, Clarian Cardiovascular CenterIndianapolisUSA

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