The History of Keratoplasty: A Brief Overview

  • Mark J. Mannis


The histories of keratoprosthesis and corneal allograft (penetrating keratoplasty) are complex and intimately intertwined. Of the two procedures, keratoprosthesis predates penetrating keratoplasty by almost a century and, as such, plays an important role in the development of corneal transplantation. For the contemporary corneal surgeon interested in keratoprosthesis surgery, understanding the historical landmarks of both keratoplasty and prosthokeratoplasty is important to the recognition of the obstacles we face to finding a successful artificial cornea.


Corneal Endothelium Corneal Transplantation Penetrating Keratoplasty Deep Anterior Lamellar Keratoplasty Lamellar Keratoplasty 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Mannis MJ, Mannis AA. Corneal transplantation: a history in profiles, vol. 6. Oostende: Wayenborgh Press; 1999. p. 376.Google Scholar
  2. 2.
    Mannis A. Erasmus Darwin. In: Mannis MJ, Mannis AA, editors. Corneal transplantation: a history in profiles. Oostende: J.P. Wayenborgh Press; 1999.Google Scholar
  3. 3.
    de Quengsy P. Precis au cours d’operation sur la chirurgie des yeux. Paris: Dido & Mequignon; 1789.Google Scholar
  4. 4.
    Albert D. Corneal surgery. In: Albert D, Edwards D, editors. The history of ophthalmology. Cambridge, MA: Blackwell Science; 1996.Google Scholar
  5. 5.
    Geria R. Los Albores de la queratoplastia. Arch Oftal de Buenos Aires. 1985;60:86–98.Google Scholar
  6. 6.
    Moffatt SL, Cartwright VA, Stumpf TH. Centennial review of corneal transplantation. Clin Experiment Ophthalmol. 2005;33:642–57.PubMedCrossRefGoogle Scholar
  7. 7.
    Rycroft B. The corneal graft-past, present, and future (Doyne memorial lecture). Trans Ophthalmol Soc U K. 1965;85:459–517.PubMedGoogle Scholar
  8. 8.
    Taylor D. The Doyne Lecture. Congenital cataract: the history, the nature and the practice. Eye (Lond). 1998;12(Pt 1):9–36.CrossRefGoogle Scholar
  9. 9.
    Trevor-Roper P. The history of corneal grafting. In: Casey T, editor. Corneal grafting. London: Butterworth; 1972.Google Scholar
  10. 10.
    Paton R. History of corneal grafting. In: Paton R, editor. Keratoplasty. New York: McGraw Hill; 1955.Google Scholar
  11. 11.
    Paton R. History of corneal transplantation. Int Ophthalmol Clin. 1970;10(2):181–6.PubMedGoogle Scholar
  12. 12.
    Mannis M, Krachmer J. Keratoplasty: a historical perspective. Surv Ophthalmol. 1981;25:333–8.PubMedCrossRefGoogle Scholar
  13. 13.
    Laibson P, Rapuano C. 100-year review of cornea. Ophthalmology. 1996;103:S17–28.PubMedCrossRefGoogle Scholar
  14. 14.
    Reisinger F. Die Keratoplastik: ein Versuch zur Erweiterung der Augenheilkunst. Bayerische Annalen. 1824;1:207–15.Google Scholar
  15. 15.
    Dieffenbach J. Beitragezur Verpflanzung der Hornhaut. Z die Ophthalmol (von Ammon, Ed). 1831;1:172–6.Google Scholar
  16. 16.
    Bigger S. An inquiry into the possibility of transplanting the cornea, with a view of relieving blindness (hitherto deemed incurable caused by several diseases of that structure. Dublin J Med Sci. 1837;11:408–17.CrossRefGoogle Scholar
  17. 17.
    Mannis M, Dohlman C. The artificial cornea. In: Mannis MJ, Mannis AA, editors. Corneal transplantation: a history in profiles, vol. 6. Oostende: J.P. Wayenborgh Press; 1999.Google Scholar
  18. 18.
    von Hippel A. Ueber Transplantation der Cornea. Arch Ophthalmol. 1878;24:235–56.Google Scholar
  19. 19.
    von Hippel A. Eine neue Methode der Hornhauttransplantation. Arch Ophthalmol. 1888;34:105–30.Google Scholar
  20. 20.
    Power H. Transplantation of the cornea. Int Ophthalmol Congress. 1873;4:172–6.Google Scholar
  21. 21.
    Zirm E. Eine erfolgreiche totale Keratoplastik. Arch Ophthalmol. 1906;64:580–93.Google Scholar
  22. 22.
    Thomas J. Transplantation of the cornea: a preliminary report on a series of experiments on rabbits, together with a demonstration of four rabbits with clear corneal grafts. Trans Ophthalmol Soc U K. 1930;50:127–41.Google Scholar
  23. 23.
    Thomas J. The technique of corneal transplantation as applied in a series of cases. Trans Ophthalmol Soc U K. 1935;55:373–92.Google Scholar
  24. 24.
    Elschnig A. Keratoplasty. Arch Ophthalmol. 1930;23:2014–15.Google Scholar
  25. 25.
    Filatov V. Transplantation of the cornea. Arch Ophthalmol. 1935;13:321–47.CrossRefGoogle Scholar
  26. 26.
    Filatov V. Transplantation of the cornea from preserved cadavers’ eyes. Lancet. 1937;1:395–7.Google Scholar
  27. 27.
    Castroviejo R. Keratoplasty. Comments on the technique of corneal transplantation. Source and preservation of donor’s material. Am J Ophthalmol. 1941;24:1–20.CrossRefGoogle Scholar
  28. 28.
    Castroviejo R. Keratoplasty. Comments on the technique of corneal transplantation. Source and preservation of donor’s material. Report of new instruments. Part II. Am J Ophthalmol. 1941;24:130–55.CrossRefGoogle Scholar
  29. 29.
    Paton D. The founder of the first eye bank: R. Townley Paton, MD. Refract Corneal Surg. 1991;7:190–5.PubMedGoogle Scholar
  30. 30.
    Maumenee A. The immune concept: its relationship to corneal transplantation. Ann N Y Acad Sci. 1955;59:453–61.PubMedCrossRefGoogle Scholar
  31. 31.
    Aiken-O’Neill P, Mannis M. The evolution of eye banking in the United States: Landmarks in the history of the Eye Bank Association of America. Int J Eye Banking. Minneapolis, 2012;1:45–7.Google Scholar
  32. 32.
    Melles GR. Posterior lamellar keratoplasty. Arch Soc Esp Oftalmol. 2002;77(4):175–6.PubMedGoogle Scholar
  33. 33.
    Melles GR. Posterior lamellar keratoplasty: DLEK to DSEK to DMEK. Cornea. 2006;25(8):879–81.PubMedCrossRefGoogle Scholar
  34. 34.
    Melles GR, Ong TS, Ververs B, van der Wees J. Descemet membrane endothelial keratoplasty (DMEK). Cornea. 2006;25(8):987–90.PubMedCrossRefGoogle Scholar
  35. 35.
    Melles GR, Ong TS, Ververs B, van der Wees J. Preliminary clinical results of Descemet membrane endothelial keratoplasty. Am J Ophthalmol. 2008;145(2):222–7.PubMedCrossRefGoogle Scholar
  36. 36.
    Terry MA. Endothelial keratoplasty: history, current state, and future directions. Cornea. 2006;25(8):873–8.PubMedCrossRefGoogle Scholar
  37. 37.
    Cornea Donor Study Investigator Group. The effect of donor age on corneal transplant outcome. Ophthalmology. 2008;115:620–6.PubMedCentralCrossRefGoogle Scholar
  38. 38.
    Cornea Donor Study Investigator Group. Donor age and corneal endothelial cell loss 5 years after successful corneal transplantation: Specular Microscopy Ancillary Study results. Ophthalmology. 2008;115:627–32.PubMedCentralCrossRefGoogle Scholar
  39. 39.
    Sugar A, Tanner J, Dontchev M, et al. Recipient risk factors for graft failure in the Cornea Donor Study. Ophthalmology. 2009;116:1023–8.PubMedCentralPubMedCrossRefGoogle Scholar
  40. 40.
    Sugar J, Montoya M, Dontchev M, et al. Donor risk factors for graft failure in the Cornea Donor Study. Cornea. 2009;28:981–5.PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Ophthalmology and Vision ScienceUniversity of California Davis Health System Eye CenterSacramentoUSA

Personalised recommendations