Abstract
Autoimmune pancreatitis (AIP) is a rare disease that has recently emerged as a unique type of pancreatitis with a presumed autoimmune etiology. In 1995, Yoshida et al. [1] proposed AIP as a diagnostic entity. They summarized the clinical features of AIP as follows: increased serum γ-globulin or immunoglobulin (Ig)G levels and the presence of autoantibodies; diffuse irregular narrowing of the main pancreatic duct (MPD) and enlargement of the pancreas; occasional association with stenosis of the lower bile duct and other autoimmune diseases; mild symptoms, usually without acute attacks of pancreatitis; effectiveness of steroid therapy; and histological findings of lymphoplasmacytic sclerosing pancreatitis (LPSP) [1, 2]. Thereafter, AIP has been extensively reported worldwide including from Japan, Korea, Europe, and the United States. Because AIP is a relatively new clinical entity and the diagnostic criteria are being established, the epidemiology of AIP is not fully known. In Japan, the Research Committee of Intractable Pancreatic Disease provided by the Ministry of Health, Labour, and Welfare of Japan (RCIPD) has conducted three nationwide epidemiological surveys of AIP according to the diagnostic criteria used at that time. We here describe the epidemiology of AIP, mainly focusing on the results of nationwide surveys in Japan [3, 4].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Yoshida K, Toki F, Takeuchi T, Watanabe S, Shiratori K, Hayashi N. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci. 1995;40:1561–8.
Kamisawa T, Notohara K, Shimosegawa T. Two clinicopathologic subtypes of autoimmune pancreatitis: LPSP and IDCP. Gastroenterology. 2010;139:22–5.
Nishimori I, Tamakoshi A, Otsuki M, Research Committee on Intractable Diseases of the Pancreas, Ministry of Health, Labour and Welfare of Japan. Prevalence of autoimmune pancreatitis in Japan from a nationwide survey in 2002. J Gastroenterol. 2007;42(Suppl. 18):6–8. doi:10.1007/s00535-007-2043-y.
Kanno A, Nishimori I, Masamune A, Kikuta K, Hirota M, Kuriyama S, Tsuji I, Shimosegawa T, Research Committee on Intractable Diseases of P. Nationwide epidemiological survey of autoimmune pancreatitis in Japan. Pancreas. 2012;41(6):835–9. doi:10.1097/MPA.0b013e3182480c99.
Members of the Criteria Committee for Autoimmune Pancreatitis of the Japan Pancreas Society. Diagnostic criteria for autoimmune pancreatitis by the Japan Pancreas Society (2002). (in Japanese with English abstract) Suizo. 2002;17:585–7.
Members of the Autoimmune Pancreatitis Diagnostic Criteria Committee, the Research Committee of Intractable Diseases of the Pancreas supported by the Japanese Ministry of Health, Labor and Welfare, and Members of the Autoimmune Pancreatitis Diagnostic Criteria Committee, the Japan Pancreas Society. Clinical diagnostic criteria of autoimmune pancreatitis 2006. (in Japanese with English abstract) Suizo. 2006;21:395–7.
Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344:732–8.
Shimosegawa T, Chari ST, Frulloni L, et al. International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology. Pancreas. 2011;40:352–8.
Okazaki K, Shimosegawa T, The Working Group Members of the Japan Pancreas Society and the Research Committee for Intractable Pancreatic Disease by the Ministry of Labor, Health and Welfare of Japan. The Amendment of the clinical diagnostic criteria in Japan (JPS2011) in response to the proposal of the international consensus of diagnostic criteria (ICDC) for autoimmune pancreatitis. Pancreas. 2012;41:1341–2.
Kamisawa T, Chari ST, Giday SA, Kim MH, Chung JB, Lee KT, Werner J, Bergmann F, Lerch MM, Mayerle J, Pickartz T, Lohr M, Schneider A, Frulloni L, Webster GJ, Reddy DN, Liao WC, Wang HP, Okazaki K, Shimosegawa T, Kloeppel G, Go VL. Clinical profile of autoimmune pancreatitis and its histological subtypes: an international multicenter survey. Pancreas. 2011;40(6):809–14. doi:10.1097/MPA.0b013e3182258a15.
Hart PA, Kamisawa T, Brugge WR, Chung JB, Culver EL, Czako L, Frulloni L, Go VL, Gress TM, Kim MH, Kawa S, Lee KT, Lerch MM, Liao WC, Lohr M, Okazaki K, Ryu JK, Schleinitz N, Shimizu K, Shimosegawa T, Soetikno R, Webster G, Yadav D, Zen Y, Chari ST. Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis. Gut. 2013;62(12):1771–6. doi:10.1136/gutjnl-2012-303617.
Acknowledgment
This work was supported in part by the Research Committee of Intractable Pancreatic Disease (principal investigator: Tooru Shimosegawa) provided by the Ministry of Health, Labour, and Welfare of Japan.
Disclosure
All authors disclosed no financial relationships relevant to this publication.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kanno, A., Masamune, A., Shimosegawa, T. (2015). Epidemiology of Autoimmune Pancreatitis. In: Kamisawa, T., Chung, J. (eds) Autoimmune Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55086-7_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-55086-7_2
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-55085-0
Online ISBN: 978-3-642-55086-7
eBook Packages: MedicineMedicine (R0)