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Systems Biology: Developments and Applications

Abstract

Systems biology relies on systems theory concepts and is applicable to both fundamental studies of cellular biology as well as applied research such as metabolic engineering. In this chapter, we map the context of systems biology developments and highlight its contribution in understanding the yeast carbon metabolism. Systems biology not only contributes towards the global overview of metabolism but also in combination with an integrative analysis approach facilitates the elucidation of molecular mechanisms. In particular we discuss the role of systems biology in unraveling the molecular details concerning glucose and galactose metabolism. In conclusion, this chapter provides an overview of the progress and impact of systems biology in carbon metabolism.

Keywords

  • Chemostat Culture
  • Glucose Repression
  • Central Carbon Metabolism
  • Genome Scale Model
  • Diauxic Shift

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Fig. 4.1
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Acknowledgments

We acknowledge financial support from UNICELLSYS and European Research Council.

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Correspondence to Jens Nielsen .

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Kumar, R., Lahtvee, PJ., Nielsen, J. (2014). Systems Biology: Developments and Applications. In: Piškur, J., Compagno, C. (eds) Molecular Mechanisms in Yeast Carbon Metabolism. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55013-3_4

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