Skip to main content

Inotropika und Vasopressoren

  • Chapter
  • First Online:
  • 24k Accesses

Zusammenfassung

Katecholamine und Vasopressoren gehören zu den in der Intensivmedizin am häufigsten eingesetzten Medikamenten. Sie werden bei hämodynamisch instabilen Patienten verwendet, um durch Erhöhung des Herzzeitvolumens und/oder Korrektur des Gefäßtonus akut lebensbedrohliche Situationen abzuwenden. Umso befremdlicher ist es daher, dass sich die Evidenz zu dieser Substanzgruppe im Wesentlichen auf Studien gründet, die lediglich hämodynamische Endpunkte untersucht haben. Untersuchungen zur Auswirkung der verschiedenen Substanzen auf harte Endpunkte wie Morbidität und Letalität fehlen nahezu vollständig. Die Indikationsstellung zur Katecholamintherapie und die Wahl einer bestimmten Substanz müssen sich daher am physiologischen Wirkspektrum, an der sog. „Expertenmeinung“ und an der klinischen Routine des jeweiligen Anwenders orientieren.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   389.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Literatur

  • Bangash MN, Kong ML, Pearse RM (2012) Use of inotropes and vasopressor agents in critically ill patients. Br J Pharmacol 165:2015–2033

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J (2000) Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 356:2139–2143

    Article  CAS  PubMed  Google Scholar 

  • Communal C, Singh K, Pimentel DR, Colucci WS (1998) Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. Circulation 98:1329–1334

    Article  CAS  PubMed  Google Scholar 

  • De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P, Gottignies P, Vincent JL (2010) Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med 362:779–789

    Article  PubMed  Google Scholar 

  • De Backer D, Aldecoa C, Njimi H, Vincent JL (2012) Dopamine versus norepinephrine in the treatment of septic shock: a meta-analysis*. Crit Care Med 40:725–730

    Article  PubMed  Google Scholar 

  • Debaveye YA, Van den Berghe GH (2004) Is there still a place for dopamine in the modern intensive care unit? Anesth Analg 98:461–468

    Article  PubMed  Google Scholar 

  • Fellahi JL, Fischer MO, Daccache G, Gerard JL, Hanouz JL (2013) Positive inotropic agents in myocardial ischemia-reperfusion injury: a benefit/risk analysis. Anesthesiology 118:1460–1465

    Article  PubMed  Google Scholar 

  • Grossini E, Caimmi PP, Molinari C, Teodori G, Vacca G (2005) Hemodynamic effect of intracoronary administration of levosimendan in the anesthetized pig. J Cardiovasc Pharmacol 46:333–342

    Article  CAS  PubMed  Google Scholar 

  • Haikala H, Kaivola J, Nissinen E, Wall P, Levijoki J, Linden IB (1995) Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan. J Mol Cell Cardiol 27:1859–1866

    Article  CAS  PubMed  Google Scholar 

  • Irlbeck M, Fechner M, Zwissler B (2012) Herz-Kreislauf-wirksame Medikamente. In: Rossaint R, Werner C, Zwissler B (Hrsg) Die Anästhesiologie. Allgemeine und spezielle Anästhesiologie, Schmerztherapie und Intensivmedizin, 3. Aufl. Springer, Berlin Heidelberg New York, S 331–351

    Google Scholar 

  • Kivikko M, Antila S, Eha J, Lehtonen L, Pentikainen PJ (2002) Pharmacokinetics of levosimendan and its metabolites during and after a 24-hour continuous infusion in patients with severe heart failure. Int J Clin Pharmacol Ther 40:465–471

    Article  CAS  PubMed  Google Scholar 

  • Landry DW, Oliver JA (2001) The pathogenesis of vasodilatory shock. N Engl J Med 345:588–595

    Article  CAS  PubMed  Google Scholar 

  • Lawson NW, Johnson JO (2001) Autonomic Nervous System: Physiology and Pharmacology. In: Barash PG, Cullen BF, Stoelting RK (Hrsg) Clinical Anesthesia, 4. Aufl. Lippincott Williams & Wilkins, Philadelphia, S 261–325

    Google Scholar 

  • Levy B (2005) Bench-to-bedside review: Is there a place for epinephrine in septic shock? Crit Care 9:561–565

    Article  PubMed Central  PubMed  Google Scholar 

  • Li HT, Long CS, Rokosh DG, Honbo NY, Karliner JS (1995) Chronic hypoxia differentially regulates alpha 1-adrenergic receptor subtype mRNAs and inhibits alpha 1-adrenergic receptor-stimulated cardiac hypertrophy and signaling. Circulation 92:918–925

    Article  CAS  PubMed  Google Scholar 

  • Lilleberg J, Nieminen MS, Akkila J, Heikkila L, Kuitunen A, Lehtonen L, Verkkala K, Mattila S, Salmenpera M (1998) Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting. Eur Heart J 19:660–668

    Article  CAS  PubMed  Google Scholar 

  • Modest VE, Butterworth JF (1995) Effect of pH and lidocaine on beta-adrenergic receptor binding. Interaction during resuscitation? Chest 108:1373–1379

    Article  CAS  PubMed  Google Scholar 

  • Overgaard CB, Dzavik V (2008) Inotropes and vasopressors: review of physiology and clinical use in cardiovascular disease. Circulation 118:1047–1056

    Article  PubMed  Google Scholar 

  • Persichini R, Silva S, Teboul JL, Jozwiak M, Chemla D, Richard C, Monnet X (2012) Effects of norepinephrine on mean systemic pressure and venous return in human septic shock. Crit Care Med 40:3146–3153

    Article  CAS  PubMed  Google Scholar 

  • Pollesello P, Mebazaa A (2004) ATP-dependent potassium channels as a key target for the treatment of myocardial and vascular dysfunction. Curr Opin Crit Care 10:436–441

    Article  PubMed  Google Scholar 

  • Singh K, Xiao L, Remondino A, Sawyer DB, Colucci WS (2001) Adrenergic regulation of cardiac myocyte apoptosis. J Cell Physiol 189:257–265

    Article  CAS  PubMed  Google Scholar 

  • Sun D, Huang A, Mital S, Kichuk MR, Marboe CC, Addonizio LJ, Michler RE, Koller A, Hintze TH, Kaley G (2002) Norepinephrine elicits beta2-receptor-mediated dilation of isolated human coronary arterioles. Circulation 106:550–555

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rex, S. (2015). Inotropika und Vasopressoren. In: Marx, G., Muhl, E., Zacharowski, K., Zeuzem, S. (eds) Die Intensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54953-3_34

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-54953-3_34

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54952-6

  • Online ISBN: 978-3-642-54953-3

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics