Zusammenfassung
Katecholamine und Vasopressoren gehören zu den in der Intensivmedizin am häufigsten eingesetzten Medikamenten. Sie werden bei hämodynamisch instabilen Patienten verwendet, um durch Erhöhung des Herzzeitvolumens und/oder Korrektur des Gefäßtonus akut lebensbedrohliche Situationen abzuwenden. Umso befremdlicher ist es daher, dass sich die Evidenz zu dieser Substanzgruppe im Wesentlichen auf Studien gründet, die lediglich hämodynamische Endpunkte untersucht haben. Untersuchungen zur Auswirkung der verschiedenen Substanzen auf harte Endpunkte wie Morbidität und Letalität fehlen nahezu vollständig. Die Indikationsstellung zur Katecholamintherapie und die Wahl einer bestimmten Substanz müssen sich daher am physiologischen Wirkspektrum, an der sog. „Expertenmeinung“ und an der klinischen Routine des jeweiligen Anwenders orientieren.
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Rex, S. (2015). Inotropika und Vasopressoren. In: Marx, G., Muhl, E., Zacharowski, K., Zeuzem, S. (eds) Die Intensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54953-3_34
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