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Pharmakodynamik und Pharmakokinetik beim Intensivpatienten, Interaktionen

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Die Intensivmedizin

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Zusammenfassung

Die Pharmakodynamik beschreibt die Einflüsse eines Pharmakons auf den Organismus, befasst sich also mit der Art und Weise seiner biologischen Wirkungen. Sie beinhaltet Überlegungen zu Wirkungsmechanismen, Rezeptortheorien, Dosis-Wirkungs-Beziehungen und Nebenwirkungen.

Pharmaka sind in der Lage, sowohl spezifische Wirkungen, die über Rezeptoren vermittelt werden, als auch unspezifische Wirkungen, die meist von den physikalischen Eigenschaften der Substanz abhängig und nicht rezeptorabhängig sind, zu vermitteln. Zur Auslösung spezifischer Wirkungen sind, anders als bei den unspezifischen Wirkungen, nur relativ niedrige Dosen bzw. Konzentrationen des Pharmakons notwendig, und es gibt einen genau definierbaren Angriffsort. Sowohl die spezifische als auch die unspezifische Bindung eines Wirkstoffes führt zu charakteristischen Veränderungen auf subzellulärer und molekularer Ebene, die zu wenigen grundlegenden Reaktionsmustern zusammengefasst werden können.

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Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Innere Medizin I, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland

    Priv.-Doz. Dr. med. Julia Langgartner

Authors
  1. Priv.-Doz. Dr. med. Julia Langgartner
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Editor information

Editors and Affiliations

  1. Klinik für Anästhesiologie, RWTH Aachen Universitätsklinikum Aachen, Aachen, Germany

    Gernot Marx

  2. Klinik für Chirurgie, Universitätsklinikum Schleswig-Holstein Campus Lübeck, Lübeck, Germany

    Elke Muhl

  3. Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Goethe-Universität Frankfurt, Frankfurt, Hessen, Germany

    Kai Zacharowski

  4. Medizinische Klinik I, Universitätsklinikum Frankfurt, Frankfurt, Germany

    Stefan Zeuzem

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Langgartner, J. (2015). Pharmakodynamik und Pharmakokinetik beim Intensivpatienten, Interaktionen. In: Marx, G., Muhl, E., Zacharowski, K., Zeuzem, S. (eds) Die Intensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54953-3_31

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  • DOI: https://doi.org/10.1007/978-3-642-54953-3_31

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54952-6

  • Online ISBN: 978-3-642-54953-3

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