Abstract
Many of the mechanisms underlying neural development are basically similar in vertebrates and invertebrates. Among vertebrates, popular species for experimental studies are zebrafish, the South African clawed toad, the chick embryo and mice. In mice, many spontaneously occurring mutations affecting the cerebral cortex and the cerebellum have been described. Their molecular analysis, combined with transgenic technology to achieve ectopic gene expression and targeted gene ablation, has made the mouse the mammal of choice for molecular genetic studies of early development.
In this chapter mechanisms of development will be discussed with emphasis on neural induction (Sect. 2.2), cell lineage studies and fate mapping (Sect. 2.3), pattern formation of the forebrain and the hindbrain (Sect. 2.4), neurogenesis, gliogenesis and migration, of the cerebral cortex in particular (Sect. 2.5), axon outgrowth and guidance, focussing on the corpus callosum, the pyramidal tract and thalamocortical projections (Sect. 2.6), and programmed cell death (Sect. 2.7).
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ten Donkelaar, H.J. (2014). Mechanisms of Development. In: Clinical Neuroembryology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54687-7_2
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