Silicon-Based Platform for Biosensing Applications

  • Yao He
  • Yuanyuan Su
Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)


Development of high-performance biosensors vastly facilitates the analysis and detection of various biological species, including nucleic acids, protein, cell, etc. Functional nanomaterials (e.g., silver/gold nanoparticles, carbon nanotubes, graphene, silicon nanowires, etc) serve as new platform for design of nano-biosensors featuring high sensitivity and specificity. Taking advantage of the attractive merits of silicon nanowires (SiNWs) (e.g., unique electronic/optical properties, huge surface-to-volume rations, surface tailorability, fast response and good reproducibility, and compatibility with conventional silicon technology), SiNWs have been widely employed for constructing various kinds of electrochemical and optical biosensors, enabling ultrasensitive, specific, and reproducible detection of DNA and protein. We introduce a number of typical SiNWs-based biosensors (e.g., field-effect transistor (FET), amperometric-, surface-enhanced Raman scattering (SERS), and fluorescence-based biosensors) in this chapter, aiming to summarize the representative progresses of this research field in recent years. These kinds of high-quality silicon-based sensors show potentially great promise for myriad practical applications, such as medical diagnosis, food safety, drug security, environment monitoring, as well as anti-bioterrorism and so forth.


Silicon nanowires Biosensor Field effect transistor Surface-enhanced Raman scattering (SERS) DNA and protein detection Sensitivity and specificity 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices and Devices Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhouChina

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