• Michael Schulze
  • Christian Stock
  • Massimo Zaccagnini
  • Dogu Teber
  • Jens J. Rassweiler
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 201)


Temsirolimus, an ester of sirolimus (rapamycin), selectively inhibits the kinase mammalian target of rapamycin (mTOR) and consequently blocks the translation of cell cycle regulatory proteins and prevents overexpression of angiogenic growth factors. It has been found to have antitumour activity in patients with relapsed or refractory mantle cell lymphoma (MCL). In addition, patients with advanced renal cell carcinoma (RCC) and a poor prognosis who received a once-weekly intravenous (IV) infusion of temsirolimus 25 mg experienced significant survival benefits compared with patients receiving standard interferon-α (IFN-α) therapy in a large phase III clinical study. In this study, median overall survival was 10.9 versus 7.3 months and objective response rates were 8.6 % in temsirolimus recipients versus 4.8 % IFN-α recipient group. Temsirolimus monotherapy recipients experienced significantly fewer grade 3 or 4 adverse events and had fewer withdrawals for adverse events than patients receiving IFN-α. The role of temsirolimus in sequential and combination therapy is yet to be found.


Vascular Endothelial Growth Factor Renal Cell Carcinoma Endometrial Carcinoma Objective Response Rate Mantle Cell Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Michael Schulze
    • 1
  • Christian Stock
    • 2
  • Massimo Zaccagnini
    • 3
  • Dogu Teber
    • 4
  • Jens J. Rassweiler
    • 1
  1. 1.Department of Urology SLK-Klinikum HeilbronnTeaching Hospital of the University of HeidelbergHeidelbergGermany
  2. 2.Department of UrologySt. Vincentius HospitalSpeyerGermany
  3. 3.Department of Urology “U. Bracci”, Policlinico Umberto IUniversity of Rome “La Sapienza”RomeItaly
  4. 4.Department of UrologyUniversity of HeidelbergHeidelbergGermany

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