Squamous cell carcinoma (SCC) of the skin is more common in fair-skinned individuals but is seen in all races. Although it is less common in skin of color, it is marked by worse prognosis, with mortality rates ranging from 17 to 30 %. SCC in populations with darker skin is less likely to be related to ultraviolet radiation and more likely related to unremitting ulcers, scars, and other chronic inflammatory processes compared to populations with lighter skin. Recent surveys revealed significant false perceptions among patients that dark skin confers complete protection from skin cancer, thus signifying the need to provide better education regarding this entity in skin of color. This chapter characterizes the epidemiology, clinical features, differential diagnosis, prognosis, and treatment of SCC in skin of color.
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