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Animal Models

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Filaggrin

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Abstract

The roles of human filaggrin in health and disease have been modeled with experimental animal models, mostly mice. Mouse models have provided important information relevant to the roles of filaggrin, but it must always be considered that mice are not humans and that the role of filaggrin in skin pathology and/or physiology still remains unclear. Most altered expression levels or pattern of filaggrin could appear as a result of abnormal keratinization and may not be substantial. In this chapter, various mutant mice and other animal models for filaggrin research are introduced.

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Author information

Authors and Affiliations

  1. Department of Dermatology, Kagawa University, 1750-1 Ikenobe, miki-cho, Kita-gun, Kagawa, 761-0793, Japan

    Kozo Nakai MD, PhD, Kozo Yoneda MD, PhD & Yasuo Kubota MD, PhD

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  1. Kozo Nakai MD, PhD
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  2. Kozo Yoneda MD, PhD
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  3. Yasuo Kubota MD, PhD
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Correspondence to Kozo Nakai MD, PhD .

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Editors and Affiliations

  1. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

  2. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Nakai, K., Yoneda, K., Kubota, Y. (2014). Animal Models. In: Thyssen, J., Maibach, H. (eds) Filaggrin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54379-1_7

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  • DOI: https://doi.org/10.1007/978-3-642-54379-1_7

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