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Filaggrin pp 23–26Cite as

Stratum Corneum Lipids and Filaggrin

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Abstract

Stratum corneum, the most upper layer of the skin, plays a key role for the skin barrier function. The stratum corneum mainly consists of corneocytes and lipids. The lipids are divided into ceramides, cholesterol, and free fatty acids. The synthesis of the lipids is regulated by enzymes, and the enzymes are influenced by pH due to the various pH optima of the different enzymes involved.

As filaggrin breakdown products contribute to the acidic pH of the stratum corneum, there is a possibility that filaggrin deficiency could influence stratum corneum lipids. However, despite people with a filaggrin gene mutation having a more neutral pH, the influence on the lipids is likely to be minimal.

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Authors and Affiliations

  1. Department of Dermatology, Roskilde Hospital, Køgevej 7-13, Roskilde, 4000, Denmark

    Jakob Mutanu Jungersted MD, PhD

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  1. Jakob Mutanu Jungersted MD, PhD
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Correspondence to Jakob Mutanu Jungersted MD, PhD .

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Editors and Affiliations

  1. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

  2. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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© 2014 Springer-Verlag Berlin Heidelberg

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Jungersted, J.M. (2014). Stratum Corneum Lipids and Filaggrin. In: Thyssen, J., Maibach, H. (eds) Filaggrin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54379-1_3

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  • DOI: https://doi.org/10.1007/978-3-642-54379-1_3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54378-4

  • Online ISBN: 978-3-642-54379-1

  • eBook Packages: MedicineMedicine (R0)

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