Laboratory Findings of Patients with Hydatidosis of the Central Nervous System
Clinical assessment of laboratory information is complex and is based on laboratory results and parasitological, histological, and immunological tests. The aim of hematologic tests is to look for eosinophilia, leucocytosis, elevation of the erythrocyte sedimentation rate, and possible anemia. The presence of eosinophilic cells in the sediment of the liquor and the presence of protoscoleces and hooklets is important for the diagnosis of hydatidosis of the central nervous system (CNS). The parasitological tests used involve macroscopic views of the surgically removed specimens as well as microscopic examination of centrifuged hydatid fluid looking for protoscoleces and hooklets. Histological examination of the affected tissue and membrane of the cysts is necessary. Immunological methods are an important part of the diagnostic procedures: indirect hemagglutination assays, immunofluorescent tests, enzyme linked immunosorbent assays, and enzyme linked immunoelectrotransfer blots. Polymerase chain reaction is a biomolecular method suitable for differentiation between Echinococcus granulosus and E. multilocularis. Clinical experience shows the need for combining two sensitive serological tests to achieve a more precise diagnosis of hydatidosis of the CNS .
KeywordsHydatid Cyst Cystic Echinococcosis Recombinant Antigen Alveolar Echinococcosis Immunological Method
Thanks are due to Mr. Georgy Kerelov and Dr. Irina Marinova for operative collaboration in preparing the text and references. I would especially like to send my sincerest thanks to Fuad Sami Haddad for his critical comments and English language revision of the text.
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