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PET and SPECT in Neurology pp 525–545Cite as

PET in Brain Arteriovenous Malformations and Cerebral Proliferative Angiopathy

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Abstract

A brain arteriovenous malformation (BAVM) is a neurovascular entity that consists of a localized dense network of abnormal blood vessels (a nidus) that holds arteries shunting directly into veins in the absence of a capillary bed. In their natural history, BAVMs carry a risk of hemorrhage or other neurological complications, for which reason they are frequently treated. Cerebral proliferative angiopathy (CPA) is a different type of neurovascular malformation with distinct angiographic and clinical features that can be used to differentiate it from a classical BAVM. The basic difference between CPA and a BAVM is that CPA has normal brain tissue intermingled in between its network of vessels. Treatment of CPA by surgery, radiosurgery, or embolization consequently harbors a high risk of neurological complications. As such, reliable diagnostic discrimination between CPA and BAVM is crucial to adequately treat patients. However, despite the fact that CPA has some characteristic imaging features, the differentiation between CPA and a brain AVM may be difficult. PET imaging as a technique that reveals functional brain tissue is therefore likely to be of additional diagnostic value.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands

    J. Marc C. van Dijk MD, PhD

  2. Department of Medical Imaging, Toronto Western Hospital, University Health Network, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada

    Timo Krings MD, PhD, FRCP(C)

  3. Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9713GZ, The Netherlands

    Janine Doorduin PhD & Riemer H. J. A. Slart MD, PhD

Authors
  1. J. Marc C. van Dijk MD, PhD
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  2. Timo Krings MD, PhD, FRCP(C)
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  3. Janine Doorduin PhD
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  4. Riemer H. J. A. Slart MD, PhD
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Corresponding author

Correspondence to J. Marc C. van Dijk MD, PhD .

Editor information

Editors and Affiliations

  1. Dept. of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

    Rudi A.J.O. Dierckx

  2. Faculty of Electrical Engineering and Information Technology, University of Applied Sciences Offenburg, Offenburg, Germany

    Andreas Otte

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Erik F.J. de Vries

  4. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Aren van Waarde

  5. Neurology, University Medical Center Groningen, Groningen, The Netherlands

    Klaus L. Leenders

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© 2014 Springer-Verlag Berlin Heidelberg

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van Dijk, J.M.C., Krings, T., Doorduin, J., Slart, R.H.J.A. (2014). PET in Brain Arteriovenous Malformations and Cerebral Proliferative Angiopathy. In: Dierckx, R., Otte, A., de Vries, E., van Waarde, A., Leenders, K. (eds) PET and SPECT in Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54307-4_23

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  • DOI: https://doi.org/10.1007/978-3-642-54307-4_23

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  • Publisher Name: Springer, Berlin, Heidelberg

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