Vascular Dementia

  • Hee Jin Kim
  • Cindy W. Yoon
  • Byoung Seok Ye
  • Eun-Joo Kim
  • Sang Won Seo
  • Jee H. Jeong
  • Duk L. Na


Vascular dementia (VaD) is a cognitive syndrome associated with cerebrovascular disease and clinically relevant ischemic or hemorrhagic lesions. It represents a group of disorders of heterogeneity, encompassing strategic infarct dementia, multi-infarct dementia, and subcortical vascular dementia. Brain lesions arising from vascular insult and subsequent clinical symptoms of patients with VaD are related to regional hypometabolism or ischemia/hypoperfusion. These can be diagnosed and measured using positron emission tomography (PET) and single-photon emission computed tomography (SPECT) techniques. In this chapter, we describe characteristics of PET and SPECT that are associated with clinical phenotypes in strategic infarct dementia, multi-infarct dementia, and subcortical vascular dementia.


Positron Emission Tomography White Matter Hyperintensities Oxygen Extraction Fraction Amyloid Positron Emission Tomography Thalamic Infarction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Alzheimer’s disease


Autosomal dominant retinal vasculopathy with cerebral leukodystrophy


Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy


Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy


Cerebral blood flow




Hexamethylpropyleneamine oxime




Multi-infarct dementia


Mini-mental state examination


Magnetic resonance imaging


National Institute of Neurological Disorders and Stroke and The Association Internationale pour la Recherche at L’Enseignement en Neurosciences


Oxygen extraction fraction


Positron emission tomography


Pittsburgh compound B


Regional cerebral metabolic rate for oxygen


Strategic infarct dementia


Single-photon emission computed tomography


Subcortical vascular dementia


Subcortical vascular cognitive impairment


Subcortical vascular mild cognitive impairment


Vascular dementia


White matter hyperintensities



This study was supported by grants from Samsung Medical Center Clinical Research Development Program (CRL-108011 and CRS 110-14-1) and by the Converging Research Center Program through the Ministry of Education, Science and Technology (2010K001054).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Hee Jin Kim
    • 1
  • Cindy W. Yoon
    • 3
  • Byoung Seok Ye
    • 2
  • Eun-Joo Kim
    • 4
  • Sang Won Seo
    • 1
  • Jee H. Jeong
    • 5
  • Duk L. Na
    • 1
  1. 1.Department of NeurologySamsung Medical Center, Sungkyunkwan, University School of MedicineGangnam-gu, SeoulRepublic of Korea
  2. 2.Department of NeurologyYonsei University College of MedicineSeodaemun-gu, SeoulRepublic of Korea
  3. 3.Department of NeurologyInha University School of MedicineShinheungdong, IncheonKorea
  4. 4.Department of NeurologyMedical Research Institute, Pusan National University Hospital, Pusan National University School of MedicineSeo-gu, BusanRepublic of Korea
  5. 5.Department of NeurologyEwha Womans University Mokdong Hospital, Ewha Womans University School of MedicineYangcheongku, SeoulRepublic of Korea

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