Abstract
Stereotactic radiotherapy involves the precise positioning of the tumor in three-dimensional space by appropriate scanning and the delivery of ionizing radiation to the tumor from multiple directions [1]. A high dose of radiation is therefore focused at the target with relatively little irradiation of the surrounding healthy tissues.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
McKenzie MR, Ma R, Clark B, et al. Stereotactic radiosurgery and radiation therapy in British Columbia. B C Med J. 2001;43:567–72.
Langmann G, Wackernagel W, Stucklschweiger G, Feichtinger K, Papaefthymiou G, Faulborn J. [Dose-volume histogram regression analysis of uveal melanomas after single fraction gamma knife radiosurgery]. Ophthalmologe. 2004;101(11):1111–9.
Langmann G, Pendl G, Mullner K, Feichtinger KH, Papaefthymiouaf G. High-compared with low-dose radiosurgery for uveal melanomas. J Neurosurg. 2002;97(5 Suppl):640–3.
Zehetmayer M, Menapace R, Kitz K, Ertl A. Suction fixation system for stereotactic radiosurgery of intraocular malignancies. Acta Neurochir Suppl. 1995;63:115–8.
Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chir Scand. 1951;102(4):316–9.
Wackernagel W, Holl E, Tarmann L, Avian A, Schneider MR, Kapp K, et al. Visual acuity after gamma-knife radiosurgery of choroidal melanomas. Br J Ophthalmol. 2013;97(2):153–8.
Dinca EB, Yianni J, Rowe J, Radatz MW, Preotiuc-Pietro D, Rundle P, et al. Survival and complications following gamma knife radiosurgery or enucleation for ocular melanoma: a 20-year experience. Acta Neurochir. 2012;154(4):605–10.
Modorati G, Miserocchi E, Galli L, Picozzi P, Rama P. Gamma knife radiosurgery for uveal melanoma: 12 years of experience. Br J Ophthalmol. 2009;93(1):40–4.
Zehetmayer M, Kitz K, Menapace R, Ertl A, Heinzl H, Ruhswurm I, et al. Local tumor control and morbidity after one to three fractions of stereotactic external beam irradiation for uveal melanoma. Radiother Oncol. 2000;55(2):135–44.
Rennie I, Forster D, Kemeny A, Walton L, Kunkler I. The use of single fraction Leksell stereotactic radiosurgery in the treatment of uveal melanoma. Acta Ophthalmol Scand. 1996;74(6):558–62.
Marchini G, Babighian S, Tomazzoli L, Gerosa MA, Nicolato A, Bricolo A, et al. Stereotactic radiosurgery of uveal melanomas: preliminary results with Gamma Knife treatment. Stereotact Funct Neurosurg. 1995;64 Suppl 1:72–9.
Logani S, Cho AS, Ali BH, Withers HR, McBride WH, Kozlov KL, et al. Single-dose compared with fractionated-dose radiation of the OM431 choroidal melanoma cell line. Am J Ophthalmol. 1995;120(4):506–10.
Mueller AJ, Talies S, Schaller UC, Hoops JP, Schriever S, Kampik A, et al. [Stereotaxic precision irradiation of large uveal melanomas with the gamma knife]. Ophthalmologe. 2000;97(8):537–45.
Simonova G, Novotny Jr J, Liscak R, Pilbauer J. Leksell gamma knife treatment of uveal melanoma. J Neurosurg. 2002;97(5 Suppl):635–9.
Cohen VM, Carter MJ, Kemeny A, Radatz M, Rennie IG. Metastasis-free survival following treatment for uveal melanoma with either stereotactic radiosurgery or enucleation. Acta Ophthalmol Scand. 2003;81(4):383–8.
Dieckmann K, Georg D, Zehetmayer M, Rottenfusser A, Potter R. Stereotactic photon beam irradiation of uveal melanoma: indications and experience at the University of Vienna since 1997. Strahlenther Onkol. 2007;183 Spec No 2:11–3.
Muller K, Nowak PJ, de Pan C, Marijnissen JP, Paridaens DA, Levendag P, et al. Effectiveness of fractionated stereotactic radiotherapy for uveal melanoma. Int J Radiat Oncol Biol Phys. 2005;63(1):116–22.
Dieckmann K, Bogner J, Georg D, Zehetmayer M, Kren G, Potter R. A linac-based stereotactic irradiation technique of uveal melanoma. Radiother Oncol. 2001;61(1):49–56.
Petersch B, Bogner J, Dieckmann K, Potter R, Georg D. Automatic real-time surveillance of eye position and gating for stereotactic radiotherapy of uveal melanoma. Med Phys. 2004;31(12):3521–7.
Georg D, Dieckmann K, Bogner J, Zehetmayer M, Potter R. Impact of a micromultileaf collimator on stereotactic radiotherapy of uveal melanoma. Int J Radiat Oncol Biol Phys. 2003;55(4):881–91.
Weber DC, Bogner J, Verwey J, Georg D, Dieckmann K, Escude L, et al. Proton beam radiotherapy versus fractionated stereotactic radiotherapy for uveal melanomas: A comparative study. Int J Radiat Oncol Biol Phys. 2005;63(2):373–84.
Dunavoelgyi R, Dieckmann K, Gleiss A, Sacu S, Kircher K, Georgopoulos M, et al. Local tumor control, visual acuity, and survival after hypofractionated stereotactic photon radiotherapy of choroidal melanoma in 212 patients treated between 1997 and 2007. Int J Radiat Oncol Biol Phys. 2011;81(1):199–205.
Dunavoelgyi R, Dieckmann K, Gleiss A, Sacu S, Kircher K, Georgopoulos M, et al. Radiogenic side effects after hypofractionated stereotactic photon radiotherapy of choroidal melanoma in 212 patients treated between 1997 and 2007. Int J Radiat Oncol Biol Phys. 2012;83(1):121–8.
Tokuuye K, Akine Y, Sumi M, Kagami Y, Ikeda H, Kaneko A. Fractionated stereotactic radiotherapy for choroidal melanoma. Radiother Oncol. 1997;43(1):87–91.
Muller K, Nowak PJ, Luyten GP, Marijnissen JP, de Pan C, Levendag P. A modified relocatable stereotactic frame for irradiation of eye melanoma: design and evaluation of treatment accuracy. Int J Radiat Oncol Biol Phys. 2004;58(1):284–91.
Krema H, Somani S, Sahgal A, Xu W, Heydarian M, Payne D, et al. Stereotactic radiotherapy for treatment of juxtapapillary choroidal melanoma: 3-year follow-up. Br J Ophthalmol. 2009;93(9):1172–6.
Al-Wassia R, Dal Pra A, Shun K, Shaban A, Corriveau C, Edelstein C, et al. Stereotactic fractionated radiotherapy in the treatment of juxtapapillary choroidal melanoma: the McGill University experience. Int J Radiat Oncol Biol Phys. 2011;81(4):e455–62.
van den Aardweg GJ, Kilic E, de Klein A, Luyten GP. Dose fractionation effects in primary and metastatic human uveal melanoma cell lines. Invest Ophthalmol Vis Sci. 2003;44(11):4660–4.
Bornfeld N, Talies S, Anastassiou G, Schilling H, Schuler A, Horstmann GA. [Endoscopic resection of malignant melanomas of the uvea after preoperative stereotactic single dose convergence irradiation with the Leksell gamma knife]. Ophthalmologe. 2002;99(5):338–44.
Acknowledgments
The authors would like to thank their coworkers for their contributions and Heimo Bauer for his technical assistance in preparing the Figs. 15.1–15.4.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Dieckmann, K. et al. (2014). Stereotactic Radiotherapy of Uveal Melanoma. In: Damato, B., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54255-8_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-54255-8_15
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-54254-1
Online ISBN: 978-3-642-54255-8
eBook Packages: MedicineMedicine (R0)