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Mammalian Transient Receptor Potential (TRP) Cation Channels pp 403–426Cite as

TRPM2

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 222))

Abstract

TRPM2 is the second member of the transient receptor potential melastatin-related (TRPM) family of cation channels. The protein is widely expressed including in the brain, immune system, endocrine cells, and endothelia. It embodies both ion channel functionality and enzymatic ADP-ribose (ADPr) hydrolase activity. TRPM2 is a Ca2+-permeable nonselective cation channel embedded in the plasma membrane and/or lysosomal compartments that is primarily activated in a synergistic fashion by intracellular ADP-ribose (ADPr) and Ca2+. It is also activated by reactive oxygen and nitrogen species (ROS/NOS) and enhanced by additional factors, such as cyclic ADPr and NAADP, while inhibited by permeating protons (acidic pH) and adenosine monophosphate (AMP). Activation of TRPM2 leads to increases in intracellular Ca2+ levels, which can serve signaling roles in inflammatory and secretory cells through release of vesicular mediators (e.g., cytokines, neurotransmitters, insulin) and in extreme cases can induce apoptotic and necrotic cell death under oxidative stress.

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Authors and Affiliations

  1. Center for Biomedical Research, The Queen’s Medical Center, 1301 Punchbowl Street, Honolulu, HI, 96813, USA

    Malika Faouzi & Reinhold Penner

  2. John A. Burns School of Medicine, University of Hawaii Cancer Center, 1301 Punchbowl Street, Honolulu, HI, 96813, USA

    Malika Faouzi & Reinhold Penner

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  1. Malika Faouzi
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  2. Reinhold Penner
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Correspondence to Malika Faouzi or Reinhold Penner .

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  1. Laboratory Ion Channel Research Campus Gasthuisberg, KU Leuven Department Cell Mol Medicin, Leuven, Belgium

    Bernd Nilius

  2. Institut für Experimentelle u. Klinische, Pharmakologie und Toxikologie, Universität des Saarlandes, Homburg, Saarland, Germany

    Veit Flockerzi

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Faouzi, M., Penner, R. (2014). TRPM2. In: Nilius, B., Flockerzi, V. (eds) Mammalian Transient Receptor Potential (TRP) Cation Channels. Handbook of Experimental Pharmacology, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54215-2_16

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