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Electrophysiologic and Biochemical Mechanisms Underlying Malignant Ventricular Arrhythmias during Early Myocardial Ischemia

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Pathophysiology and Rational Pharmacotherapy of Myocardial Ischemia

Abstract

Sudden cardiac death accounts for over 300,000 deaths per year in the United States alone [111]. It most often occurs in the setting of diffuse coronary artery disease [9], and in about 25% of cases of sudden cardiac death, the event is the initial presentation of coronary disease [87]. Death is most often due to malignant ventricular arrhythmias including complex premature ventricular complexes or ventricular tachycardia which culminate in the development of ventricular fibrillation [23].

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  1. Cardiovascular Division, Department of Medicine and Department of Pharmacology, Washington University School of Medicine, Box 8086, 660 South Euclid Avenue, St. Louis, Missouri, 63110, USA

    Stephen M. Pogwizd & Dr. Peter B. Corr

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  1. Abteilung für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstraße 55, D-4300, Essen, Germany

    Gerd Heusch

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Pogwizd, S.M., Corr, P.B. (1990). Electrophysiologic and Biochemical Mechanisms Underlying Malignant Ventricular Arrhythmias during Early Myocardial Ischemia. In: Heusch, G. (eds) Pathophysiology and Rational Pharmacotherapy of Myocardial Ischemia. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-54133-9_7

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