Skip to main content

A Simple and Low Cost Micromixer for Laminar Blood Mixing: Design, Optimization, and Analysis

  • Conference paper
Book cover Biomedical Informatics and Technology (ACBIT 2013)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 404))

Included in the following conference series:

Abstract

The paper presents a design of micromixer for laminar blood mixing. In order to minimize the space usage for micromixer of an automatic sample collection system, a splitting and recombination (SAR) concept was employed to reduce the diffusion distance of the fluids. Moreover, ellipse-like micropillars were introduced to this concept to increase the mixing performance of micromixer. With software (COMSOL 4.3) for computational fluid dynamics (CFD) we simulated the mixing of fluids in a micromixer with ellipse-like micropillars and basic T-type mixer in a laminar flow regime. Numerical results illustrate that the micromixer with SAR concept achieves an outstanding mixing efficiency than the one without SAR concept. Numerical results also show that the SAR micromixer with ellipse-like micropillars is up to 99% efficient, and that efficiency reaches 90% in a short distance.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Nguyen, N.T., Wu, Z.: Micromixers—a review. J. Micromech. Micro eng. 16, R1–R16 (2005)

    Google Scholar 

  2. Hessel, V., Lowe, H., Schonfeld, F.: Micromixers—a review on passive and active mixing principles. Chemical Engineering Science 60, 2479–2501 (2005)

    Article  Google Scholar 

  3. Bhagat, A.A.S., Peterson, E.T.K., Papautsky, I.: A passive planar micromixer with obstructions for mixing at low Reynolds numbers. J. Micromech. Microeng. 17, 1017–1024 (2007)

    Article  Google Scholar 

  4. Wong, S.H., Ward, M.C.L., Wharton, C.W.: Micro T-mixer as a rapid mixing micromixer. Sensors and Actuators B 100, 359–379 (2004)

    Article  Google Scholar 

  5. Nguyen, T.N.T., Kim, M., Park, J., Lee, N.: An effective passive microfluidic mixer utilizing chaotic advection. Sensors and Actuators B 132, 172–181 (2008)

    Article  Google Scholar 

  6. Lee, S.W., Kim, D.S., Lee, S.S., Kwon, T.H.: Split and recombination micromixer based on PDMS three-dimensional micro structure. In: The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, Seoul, Korea, June 5-9, pp. 1533–1536 (2005)

    Google Scholar 

  7. Lee, S.W., Lee, S.S.: Rotation effect in split and recombination micromixing. Sensors and Actuators B 129, 364–371 (2008)

    Article  Google Scholar 

  8. Fanga, W., Yang, J.: A novel microreactor with 3D rotating flow to boost fluid reaction and mixing of viscous fluids. Sensors and Actuators B 140, 629–642 (2009)

    Article  Google Scholar 

  9. Chen, Z., Bown, M.R., O’Sullivan, B., MacInnes, J.M., Allen, R.W.K., Mulder, M., Blom, M., van’t Oever, R.: Performance analysis of a folding flow micromixer. Microfluid. Nanofluid. 6, 763–774 (2009)

    Article  Google Scholar 

  10. Tran-Minh, N., Dong, T., Su, Q., Yang, Z., Jakobsen, H., Karlsen, F.: Design and optimization of non-clogging counter-flow microconcentrator for enriching epidermoid cervical. Biomed. Microdevices 13, 179–190 (2011)

    Article  Google Scholar 

  11. Currie, I.G.: Fundamental Mechanics of Fluids. McGraw-Hill, Inc., New York (1993)

    Google Scholar 

  12. Handley, A.J.: Heparin therapy: A simpler test of control. J. Clin. Path. 27(3), 250–252 (1974)

    Article  Google Scholar 

  13. Dixon, E.P., Grønn, P., King, L.M., Passineau, H., Doobay, H., Skomedal, H., Hariri, J., Hay, S.N., Brown, C.A., Fischer, T.J., Malinowski, D.P.: Analytical performance of RNA isolated from BD SurePathTM cervical cytology specimens by the PreTectTM HPV-Proofer assay. Journal of Virological Methods 185(2), 199–203 (2012)

    Article  Google Scholar 

  14. Burka, E.R.: Characteristics of RNA degradation in the erythroid cell. J. Clin. Invest. 48(7), 1266–1272 (1969)

    Article  Google Scholar 

  15. Lee, S., Lee, H.-Y., Lee, I.-F., Tseng, C.-Y.: Ink diffusion in water. Eur. J. Phys. 25, 331–336 (2004)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Tran-Minh, N., Karlsen, F., Dong, T., Le-The, H. (2014). A Simple and Low Cost Micromixer for Laminar Blood Mixing: Design, Optimization, and Analysis. In: Pham, T.D., Ichikawa, K., Oyama-Higa, M., Coomans, D., Jiang, X. (eds) Biomedical Informatics and Technology. ACBIT 2013. Communications in Computer and Information Science, vol 404. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54121-6_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-54121-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54120-9

  • Online ISBN: 978-3-642-54121-6

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics