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Infectious Disease Testing

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Molecular Diagnostics for Dermatology

Abstract

Bacteria, viruses, fungi, and parasites all have nucleic acid genomes, which can be targeted by highly sensitive and specific molecular assays. Molecular assays can be designed to be highly specific to one species or capable of detecting multiple different pathogens. Over the last two decades, testing for many infectious pathogens has transitioned to molecular methods due to the limitations of culture, serology, and special stain techniques. Dermatology-related molecular infectious disease assays can be valuable for uncommon organisms and/or when the clinical and histopathologic findings are nonspecific. In this setting, assays that are capable of detecting multiple different organisms simultaneously are advantageous since they are not limited by clinical suspicion. In addition to their diagnostic use for identifying pathogens, molecular testing may have additional applications, including the identification of viral genomes in cutaneous neoplasms (for aiding in tumor diagnosis) and the identification of organisms with antimicrobial resistance.

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Notes

  1. 1.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  2. 2.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  3. 3.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  4. 4.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  5. 5.

    . The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  6. 6.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  7. 7.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  8. 8.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  9. 9.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  10. 10.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  11. 11.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  12. 12.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  13. 13.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide0 [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

  14. 14.

    The CPT codes are from 2014 listings and are provided for reference only, not as a billing guide [1]. Recommended codes may vary depending on molecular targets and testing methods. These are updated annually. A reference for physician fee schedules can be found at www.cms.gov.

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Authors and Affiliations

  1. Division of Dermatopathology, ProPath, Dallas, TX, USA

    Gregory A. Hosler M.D., Ph.D

  2. University of Texas Southwestern Medical School, Dallas, TX, USA

    Gregory A. Hosler M.D., Ph.D

  3. Clinical Laboratory Operations, ProPath, Dallas, TX, USA

    Kathleen M. Murphy Ph.D

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  1. Gregory A. Hosler M.D., Ph.D
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Hosler, G.A., Murphy, K.M. (2014). Infectious Disease Testing. In: Molecular Diagnostics for Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54066-0_11

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