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Marine-Derived Fungal Metabolites

  • Sherif S. Ebada
  • Peter Proksch

Abstract

Marine-derived metabolites continue to be a prolific source for bioactive natural products with a high tendency to become drug candidates. Recently, eribulin mesylate (E7389), a synthetic derivative of halichondrin B, was approved by the US FDA (Food and Drug Administration) for the treatment of breast cancer metastases, going under the trade name Halaven. Some other marine-derived pharmaceuticals have likewise already been approved and launched onto the market, including Yondelis (trabectedin), Prialt (ziconotide), Retrovir (zidovudine), Cytosar (cytarabine, Ara-C), and Vira-A (vidarabine, Ara-A). Research interests in marine natural products have increased in the last few decades, in particular with respect to compounds isolated from marine-derived fungi. In this chapter, a historical background of marine-derived pharmaceuticals and fungal metabolites will be presented, including potential classes of bioactive chemical compounds. In addition, a perspective on the sustainability of marine-derived fungi with regard to a continuous supply of bioactive compounds for market needs rather than a pursuit of other strategies such as aquafarming will be discussed.

Keywords

Endophytic Fungus Absolute Configuration Human Tumor Cell Line Marine Fungus Marine Natural Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
1-D

one-dimensional

2-D

two-dimensional

A549

human lung adenocarcinoma

AChE

acetylcholinesterase

AIDS

acquired immunodeficiency syndrome

ALCL

anaplastic large cell lymphoma

ATCC

American Type Culture Collection

Ara-A

arabinofuranosyl adenine or adenine arabinoside

Ara-C

arebinosyl cytosine

cytarabine

CD

circular dichroism

CHO

Chinese hamster ovary

CML

chronic myeloid leukemia

CNS

central nervous system (CNS)

Campto

camptothecin

DMXBA

3-(2,4-dimethoxybenzylidene)-anabaseine

DNA

deoxyribonucleic acid

DPPH

1,1-diphenyl-2-picrylhydrazyl

E7389

eribulin mesylate

ECD

electronic circular dichroism

EMEA

European Medicines Agency

ET-743

ecteinascidins

EtOAc

ethyl acetate

FDA

Food and Drug Administration

HBV

hepatitis B virus

HCT

human colorectal tumor

HDAC

histone deacetylase

HIV

human immunodeficiency virus

HLE

human leukocyte elastase

HMT

histone methyltransferases

HPLC

high-performance liquid chromatography

HUVEC

human umbilical vein endothelial cells

HeLa

human cervix carcinoma cells

Hep3B

human liver carcinoma

HepG2

Hepatoma Growth2

IMPDH

inosine 5 Open image in new window-monophosphate dehydrogenase

K562

human chronic myeloid leukemia cells

KB

human epidermoid carcinoma

LPS

lipopolysaccharide

MA

maslinic acid

MCF

Michigan Cancer Foundation-7

MIC

minimum inhibitory concentration

MMAE

monomethyl auristatin E

MOLT

molybdate uptake transporter

MPA

mycophenolic acid

MRSA

methicillin-resistant Staphylococcus aureus

MS

mass spectroscopy

MTT

microculture tetrazolium assay

M

mitosis

NCI-H460

human lung cancer cell line

NMR

nuclear magnetic resonance

NOESY

nuclear Overhauser and exchange spectroscopy

NRPS

nonribosomal peptide synthase

NSCLC

non-small cell lung cancer

PC

phycocyanin

PKS

polyketide synthase

PRRSV

porcine reproductive and respiratory syndrome virus

PTP1B

protein tyrosine phosphatase 1B

RAW

ATCC cell line

RT

reverse transcriptase

SAHA

suberoylanilide hydroxamic acid

SAR

structure-activity relationship

SF-268

human CNS cancer cell line

SF

surfactin

SIV

subintestinal vessel plexus

S

synthesis

TDDFT

time-dependent density functional theory

VDA

vascular disrupting agent

iNOS

inducible nitric oxide synthase

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Authors and Affiliations

  1. 1.Faculty of Pharmacy, Department of Pharmacognosy and PhytochemistryAin-Shams UniversityCairoEgypt
  2. 2.Institute of Pharmaceutical Biology and BiotechologyHeinrich-Heine UniversityDüsseldorfGermany

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