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Springer Handbook of Marine Biotechnology pp 475–495Cite as

Proteomics: Applications and Advances

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Abstract

Proteomics provides a snapshot of gene expression in a particular cell, tissue, or organ at the time of sampling. Since the proteome is the link between the genotype and phenotype of an organism, characterization of the proteome provides information regarding the adaptability and physiology of an organism in relation to its environment. Proteomics is proving invaluable as a tool in marine biotechnology, where it has been employed to identify and characterize unique bioactive gene products, characterize the function and regulation of metabolic processes, elucidate marine biodiversity, and identify biomarkers of pollution and disease. Aquaculture of commercially important marine fish and shellfish has benefitted through a proteomics approach to address issues relating to disease, larviculture, and animal production in order to improve the profitability and sustainability of the industry. This chapter describes a wide variety of studies that illustrate the application of proteomics in marine biotechnology. The rapid improvements in proteomics technology expected over the next few years are guaranteed to result in dramatic advances in our understanding and use of the valuable resources provided by the marine environment.

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Abbreviations

2D-DIGE:

two-dimensional difference in-gel electrophoresis

ABC:

ATP-binding cassette

AKG:

α-ketoglutarate

ATP:

adenosine triphosphate

BPA:

bisphenol A

Cd:

cadmium

CyDyes:

cyanine dyes

DNA:

deoxyribonucleic acid

DSP:

diarrhetic shellfish poisoning

ECP:

extracellular product

EDC:

endocrine disrupting compound

ESI:

electrospray ionization

HAB:

harmful algal bloom

HSC70:

heat-shock cognate protein 70

HSDH4:

17β-hydroxysteroid dehydrogenase type 4

ICR:

imprinting control region

IPG:

immobilized pH gradient

InHA:

immune inhibitor A precursor

KSR1:

kinase suppressor of Ras1

LC-ESI-MS:

liquid chromatography electrospray ionization mass spectrometry

LC:

liquid chromatography

LPS:

lipopolysaccharide

MALDI:

mass spectrometry using assisted laser desorption ionization

MA:

maslinic acid

MS/MS:

tandem mass spectrometry

MS:

mass spectroscopy

MeHg:

methylmercury

NADH:

nicotiamide adenine dinucleotide

NADPH:

nicotinamide adenine dinucleotide phosphate

NCBI:

National Center for Biotechnology Information

NF:

nuclear factor

NP:

nonylphenol mixture

OA:

ocean acidification

PAGE:

polyacrylamide gel electrophoresis

PCA:

principal component analysis

PCNA:

proliferative cell nuclear antigen

PES:

protein expression signature

PM:

petrosaspongiolide M

PP:

protein phosphatase

PSP:

paralytic shellfish poisoning

PST:

paralytic shellfish poisoning toxin

ProLuCID:

name of a tandem mass spectrabased protein identification program

RNA:

ribonucleic acid

ROS:

reactive oxygen species

SDS-PAGE:

polyacrylamide gel electrophoresis

SDS:

sodium dodecyl sulfate

SELDI:

surface enhanced laser desorption/ionization

SEQUEST:

tandem mass spectrometry data analysis program used for protein identification

TOF:

time of flight

Wap65:

warm temperature acclimation-related protein 65

iTRAQ:

isobaric tags relative absolute quantification

mRNA:

messenger RNA

pI:

isoelectric point

ww:

wet weight

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  1. Molecular and Cell Biology Department, University of Cape Town, 7700, Rondebosch, South Africa

    Vernon E. Coyne

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  1. Department of Marine-Bio. Convergence Science Specialized Graduate School Science & Technology Convergence Marine Bioprocess Research Center, Pukyong National University, Yongdang Campus, 365, Sinseon-ro, Nam-gu, 608-739, Busan, Korea

    Se-Kwon Kim Prof.

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Coyne, V.E. (2015). Proteomics: Applications and Advances. In: Kim, SK. (eds) Springer Handbook of Marine Biotechnology. Springer Handbooks. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-53971-8_18

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