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Inhibition of Fungal Biofilms

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Antibiofilm Agents

Part of the book series: Springer Series on Biofilms ((BIOFILMS,volume 8))

Abstract

Fungal infections constitute a major threat for an expanding population of immunosuppressed patients, as these infections carry unacceptably high morbidity and mortality rates due to, among other reasons, the limited arsenal of antifungal agents. One of the main factors complicating antifungal therapy is the formation of fungal biofilms, resulting in frank resistance to most antifungal drugs, which is multifactorial in nature. Although Candida albicans remains the most frequent etiologic agent of fungal biofilm infections, there is an increased recognition that infections caused by other yeasts and filamentous fungi are also associated with the formation of biofilms, both on biomedical devices and host tissues. During the last decade an increasing number of studies have begun to uncover the driving forces behind the formation of fungal biofilms and the molecular basis of biofilm resistance; together with new powerful technologies, they may pave the road for the development of newer therapeutics for the prevention and treatment of these recalcitrant infections.

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Acknowledgments

Biofilm work in the laboratory is funded by Grant numbered 1R01DE023510 from the National Institute of Dental & Craniofacial Research (to JLL-R) and by the Army Research Office of the Department of Defense under Contract No. W911NF-11-1-0136. Infectious diseases-related work in the A.K.R. laboratory is funded by NIH (SC1HL112629). CGP and AS acknowledge the receipt of predoctoral fellowships from American Heart Association, numbered 51PRE30004 and 13PRE17110093. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript, and the content is solely the responsibility of the authors.

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Authors and Affiliations

  1. Department of Biology, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA

    Christopher G. Pierce, Priya Uppuluri & José L. López-Ribot

  2. South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA

    Christopher G. Pierce, Anand Srinivasan, Priya Uppuluri, Anand K. Ramasubramanian & José L. López-Ribot

  3. Department of Biomedical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA

    Anand Srinivasan & Anand K. Ramasubramanian

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  1. Christopher G. Pierce
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  2. Anand Srinivasan
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  3. Priya Uppuluri
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  4. Anand K. Ramasubramanian
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  5. José L. López-Ribot
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Correspondence to José L. López-Ribot .

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Editors and Affiliations

  1. Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

    Kendra P. Rumbaugh

  2. Department of Ag. Microbiology, Aligarh Muslim University, Aligarh, India

    Iqbal Ahmad

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Pierce, C.G., Srinivasan, A., Uppuluri, P., Ramasubramanian, A.K., López-Ribot, J.L. (2014). Inhibition of Fungal Biofilms. In: Rumbaugh, K., Ahmad, I. (eds) Antibiofilm Agents. Springer Series on Biofilms, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-53833-9_13

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