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Echocardiographic and Flow Visualization Studies of the Mechanism for Systolic Anterior Motion of the Mitral Valve In Hypertrophic Cardiomyopathy

  • Elizabeth R. Gieseking
  • Xavier P. Lefebvre
  • Edward G. Cape
  • Robert A. Levine
  • Ajit P. Yoganathan
Conference paper

Abstract

Obstructive hypertrophic cardiomyopathy is characterized by a thickened interventricular septum and systolic anterior motion (SAM) of the mitral valve. This study tested a new hypothesis for SAM which stresses primary structural abnormalities of the papillary muscles using an in vitro model of the left ventricle. Echocardiographic observations revealed creation of SAM by anterior and inward displacement of the papillary muscles. Septal thickening alone, the basis of the currently accepted Venturi theory, did not produce SAM. Flow visualization studies confirmed the importance of drag forces in the maintenance of SAM as streamlines were observed to impact on the residual anterior leaflet which was interposed into ventricular outflow.

Keywords

Mitral Valve Outflow Tract Papillary Muscle Hypertrophic Cardiomyopathy Axis View 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Wigle ED: Hypertrophic cardiomyopathy: a 1987 viewpoint. Circulation 75: 311–322, 1987.CrossRefGoogle Scholar
  2. 2.
    Jiang L, Levine RA, King ME, et al: An integrated mechanism for systolic anterior motion based on echocardiographic observations. Am Heart J 113: 633–544, 1987.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Elizabeth R. Gieseking
    • 1
  • Xavier P. Lefebvre
    • 1
  • Edward G. Cape
    • 1
  • Robert A. Levine
    • 1
  • Ajit P. Yoganathan
    • 1
  1. 1.Cardiovascular Fluid Dynamics LaboratorySchool of Chemical Engineering Georgia Institute of TechnologyAtlantaUSA

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