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State Dependent Blocking Effects on the Alamethicin Pore by Divalent Cations

  • W. Hanke
  • G. Boheim
Conference paper

Abstract

Free-diffusion theories have been found inadequate for describing a variety of properties of ionic fluxes in biological channels. For this reason deviations from independent movement of ions have been discussed in terms of competitive binding of different ions to discrete sites within a channel. In case of the gramicidin channel, where the inner wall is simply lined by carbonyl oxygens, related phenomena have been described. By way of example, the permeability to alkali cations is blocked in dependence on the concentration of divalent cations to which the gramicidin channel is impermeable.

Keywords

Divalent Cation Carbonyl Oxygen Competitive Binding Conductance State Independent Movement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1979

Authors and Affiliations

  • W. Hanke
    • 1
  • G. Boheim
    • 1
  1. 1.Lehrstuhl ZellphysiologieRuhr-Universität BochumBochum 1Germany

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