Abstract
The translational kinematics of cells in a polar field as electric field, concentration gradient, etc., can be described by two independent cellular responses: the speed and the direction of migration. It is shown that the speed can be described by a steerer (=controller without feedback) and the direction of migration by an automatic controller (=controller with feedback). The steerer and automatic controller can be regarded as the framework for the directed movement or growth and it can be applied even when the physico-chemical signals of the cell are unknown. The models are verified by data of human granulocytes.
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Gruler, H. (1990). Chemokinesis, Chemotaxis and Galvanotaxis Dose-Response Curves and Signal Chains. In: Alt, W., Hoffmann, G. (eds) Biological Motion. Lecture Notes in Biomathematics, vol 89. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51664-1_28
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DOI: https://doi.org/10.1007/978-3-642-51664-1_28
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