The use of Contour Plots for Interpretation of Multi-Drug Combination
A combination of more than two drugs makes it difficult to find the optimal treatment level. One way to analyse such combinations is through Regression analysis. To help in the analysis various kinds of contour plots can be generated from the Regression model used. They can be very helpful in the interpretation of the multi-relations-ships occured by the drug combinations. Where the number of interactions grows exponentially with the number of drugs used in the treatment. However, by considering combinations of constant response, the dimensions can be decreased by one, marking it easier to interpret the relationships existing between all drugs in the combination.
KeywordsResponse Surface Contour Plot Hazard Function Drug Combination Relative Hazard
Unable to display preview. Download preview PDF.
- 1.Carter, W.H., Stablein, D. M. and Wampler G.L (1979). An improved method for analysing survival data from combination chemotherapy experiments; Cancer Research 39.Google Scholar
- 2.Draper, N.R. (1963). Ridge Analysis of response surface. Technometrics 5.Google Scholar
- 3.Mead, R. and Pike, D.J. (1975). A review response surface methodology from a biometrics view point. Biometrics 31.Google Scholar
- 4.Myers, R.H. and Carter, W.H. (1973). Response surface techniques for dual response systems. Technometrics 15.Google Scholar
- 5.Stablein, D., Carter W.H., and Wampler G.L., Survival Analysis of Drug Combinations Using a Hazard Model with Time-Dependent Covariates Biometrical 36.Google Scholar
- 6.Wampler, G.L, Carter, W.H and Stablein, D.M. (1983). Regression Analysis of Survival Data in Cancer Chemotherapy. Marcel Dekker Inc.Google Scholar
- 7.Wampler, G.L, Carter, W.H., Glazier, R.L. and Kupermink, M. (1979). Dose response relationships of Adriamycine (ADR) and Cyclophosphamide (CTX) in treatment of squamous cell carcinoma. Proc.ASCO, 20.Google Scholar