Marihuana pp 93-109 | Cite as

Examination of the Metabolites of Δ1-Tetrahydrocannabinol in Mouse Liver, Heart, and Lung by Combined Gas Chromatography and Mass Spectrometry

  • D. J. Harvey
  • W. D. M. Paton


The distribution of Δ1-tetrahydrocannabinol (Δ1-THC, I) in tissues has been widely studied by radiochemical methods, and substantial accumulations have been found in certain organs, notably liver, lung, spleen, kidney, and adrenal gland [1,18,19]. Nevertheless, comparatively little is known about the nature of the accumulated material, although it is apparent that both Δ1-THC and various metabolites are present. Differences in the relative concentrations of the metabolites in tissues, particularly lung and liver, have been recognized [16], suggesting biotransformation of Δ1-THC at several sites. Several of the reported hydroxylated metabolites, in particular 7-OH-Δ1-THC (II), possess pharmacological activity [9,11], and one metabolite, 1,2-epoxide (VII) [3,12], is potentially chemically active [10]. The structures of a number of metabolites are still unknown and could contribute to the overall activity of the drug (Table 9.1) [13].


Base Peak Hydroxy Acid Methylene Unit Dihydroxy Acid Pentyl Side Chain 
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© Springer-Verlag New York Inc. 1976

Authors and Affiliations

  • D. J. Harvey
  • W. D. M. Paton

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