Abstract
Great progress has been made in recent years in elucidating the metabolism of Δ9-tetrahydrocannabinol (Δ9-THC), the major psychoactive constituent of marihuana. The main metabolites of Δ9-THC, resulting from the liver microsomal oxidase reactions, have been identified as 11-hydroxy-Δ9-THC (11-OH-Δ9-THC) and 8,11-diOH-Δ9-THC [1,3,20]. In addition, the formation of acidic metabolites has been proven [4,17,21]. Treatment of rats with SKF-525-A before administering Δ9-THC resulted in a substantial reduction of all three metabolites [7]. Some reports indicate that the monohydroxylated metabolite is as active as Δ9-THC behavior-ally and pharmacologically [8,12,19,20], although others imply that unchanged Δ9-THC is responsible for certain effects of marihuana [13,18]. The dihydroxylated product is behaviorally inactive [5,19,20].
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Schoolar, J.C., Ho, B.T., Estevez, V.S. (1976). Comparison of Various Solvent Extractions for the Chromatographic Analysis of Δ9-THC and Its Metabolites. In: Nahas, G.G., Paton, W.D.M., Idänpään-Heikkilä, J.E. (eds) Marihuana. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51624-5_6
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DOI: https://doi.org/10.1007/978-3-642-51624-5_6
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