Cannabinoids and the Inhibition of Prostaglandin Synthesis
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During the last decade, there has been a rapid expansion of interest in both prostaglandins and cannabinoids. Prostaglandins are being recognized as basic to many physiological or pathological functions, and it is not surprising that many drugs interact with them. Evidence is accumulating that Δ9-tetrahydrocannabinol (Δ9-THC) and other cannabinoidlike agents affect prostaglandin synthesis. For this to be a viable hypothesis, it is necessary to indicate clear physiological changes caused by Δ9-THC that are attributable to inhibition of prostaglandin synthesis.
KeywordsArachidonic Acid Luteinizing Hormone Intraocular Pressure Prostaglandin Synthesis Luteinizing Hormone Secretion
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- 5.Chiang, T. S. and R. P. Thomas (1972) Effects of progesterone and epinephrine on the ocular hypertensive response to intravenous infusion of prostaglandin E1. 5th International Congress on Pharmacology, abstract No. 243.Google Scholar
- 6.Crowshaw, K. and H. F. Hardman (1974) Effect of Δ9-tetrahydro-cannabinol (Δ9-THC) on prostaglandin (PG) synthesis and the relationship of this effect to the hypothermic response in mice. Fed. Proc. 33: abstract No. 1847.Google Scholar
- 7.Fereira, S. H. and S. Moncada (1971) Inhibition of prostaglandin synthesis augments the effects of sympathetic nerve stimulation on the cat spleen. Br. J. Pharmacol. 43:419P.Google Scholar
- 8.Frank, I. M., R. S. Hepler, L. Epps, J. T. Ungerleider and S. Szara (1972) Marihuana and delta-9-tetrahydrocannabinol: effects on intraocular pressure in young adults. 5th International Congress on Pharmacology, abstract No. 426.Google Scholar
- 12.Holmes, S. W. and E. W. Horton (1967) Prostaglandins and the central nervous system. Prostaglandin Symposium of the Worcester Foundation for Experimental Biology (P. W. Ramwell and S. E. Shaw, eds.). New York: Interscience Publishers, pp. 21–38.Google Scholar
- 15.Howes, J. F. and P. F. Osgood (1974) The effects of Δ9-THC and a water soluble derivative on PGE1 synthesis on the corpus striatum. Pharmacologist 16: abstract 389.Google Scholar
- 19.McGiff, J. C (1975) Prostaglandins as regulators of blood pressure. Hosp. Prac. 101.Google Scholar
- 26.Sofia, R. D., T. A. Solomon, and M. Barry, III (1971) The anticonvulsant activity of Δ1-tetrahydrocannabinol in mice. Pharmacologist 13: Abstract 309.Google Scholar