Marihuana pp 299-312 | Cite as

Inhibitory Effects of Δ9-Tetrahydrocannabinol on Nucleic Acid Synthesis and Proteins in Cultured Lymphocytes

  • Gabriel G. Nahas
  • Bernard Desoize
  • Joy Hsu
  • A. Morishima


We have reported in other publications [16, 17] that two natural psychoactive cannabinoids, Δ8- and Δ9-tetrahydrocannibinol, their hydroxylated derivatives, and four nonpsychoactive cannabinoids: cannabinol, cannabidiol, cannabichromene, and cannabicyclol, inhibit in similar concentrations (10-5 Mto 10-4 M)blastogenesis of human lymphocytes. It was suggested that this inhibitory effect of the natural cannabinoids was induced in part by olivetol or 5n-amylresorcinol, which has the structure of the C ring of these compounds.


Thymidine Incorporation Nucleic Acid Synthesis Macromolecular Synthesis Precursor Incorporation Mixed Leukocyte Culture 
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© Springer-Verlag New York Inc. 1976

Authors and Affiliations

  • Gabriel G. Nahas
  • Bernard Desoize
  • Joy Hsu
  • A. Morishima

There are no affiliations available

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