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Marihuana pp 273–281Cite as

Effect of Δ1-Tetrahydrocannabinol on Red Blood Cell Membranes and on Alveolar Macrophages

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Abstract

Recent studies involving the major constituent of hashish, Δ1-tetrahydrocannabinol (THC) [9,10], in its purified form [14] have provided important information on its pharmacological and biochemical effetcs in general, and at the membrane level in particular. THC is highly lipophilic (the expected partition coefficient, based on a corrected octanol/water partition, is 1200 [16]) and has great affinity for lipoproteins [20]. It does not demonstrate good anesthetic characteristics, and its mode of action on membranes is of a peculiar pattern.

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Authors
  1. A. Chari-Bitron
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Editors and Affiliations

  1. College of Physicians & Surgeons of Columbia University, 630 West 168th Street, 10032, New York, New York, USA

    Gabriel G. Nahas M.D., Ph.D. (Research Professor of Anesthesiology) (Research Professor of Anesthesiology)

  2. University of Oxford, Oxford, England

    William D. M. Paton M.D., Ph.D. (Professor of Pharmacology) (Professor of Pharmacology)

  3. National Board of Health, Helsinki, 53, Finland

    Juhana E. Idänpään-Heikkilä M.D., D.M.Sc. (Docent, Chief Medical Officer for Pharmacology) (Docent, Chief Medical Officer for Pharmacology)

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© 1976 Springer-Verlag New York Inc.

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Chari-Bitron, A. (1976). Effect of Δ1-Tetrahydrocannabinol on Red Blood Cell Membranes and on Alveolar Macrophages. In: Nahas, G.G., Paton, W.D.M., Idänpään-Heikkilä, J.E. (eds) Marihuana. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51624-5_24

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  • DOI: https://doi.org/10.1007/978-3-642-51624-5_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-51626-9

  • Online ISBN: 978-3-642-51624-5

  • eBook Packages: Springer Book Archive

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