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Marihuana pp 179–185Cite as

Rate of Penetration of Δ9-Tetrahydrocannabinol and 11-Hydroxy-Δ9-Tetrahydrocannabinol to the Brain of Mice

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Abstract

During investigations designed to study the clinical pharmacology and metabolism of cannabinoids, tritium-labeled Δ9-tetra-hydrocannabinol (Δ9-THC) and 11-OH-Δ9-THC were intravenously infused to normal control volunteers.

Keywords

  • Total Radioactivity
  • Brain Concentration
  • Cervical Fracture
  • Public Health Service Research
  • Percent Ethanol

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  • DOI: 10.1007/978-3-642-51624-5_15
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References

  1. Christensen, H. D., R. I. Freudenthal, J. T. Gidley, R. Rosenfeld, G. Boegli, L. Testino, D. R. Brine, C. G. Pitt, and M. E. Wall (1971) Activity of Δ8- and Δ9-tetrahydrocannabinol and related compounds in the mouse. Science 172:165.

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  2. Perez-Reyes, M., M. C. Timmons, K. H. Davis, and M. E. Wall (1973) A comparison of the pharmacological activity in man of intravenously administered Δ9-tetrahydrocannabinol, cannabinol and cannabidiol. Experientia 29:1368.

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  3. Perez-Reyes, M., M. C. Timmons, M. A. Lipton, H. D. Christensen, K. H. Davis, and M. E. Wall (1973) A comparison of the pharmacological activity of Δ9-tetrahydrocannabinol and its monohydroxyl-ated metabolites in man. Experientia 29:1009.

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  4. Perez-Reyes, M., M. C. Timmons, M. A. Lipton, K. H. Davis, and M. E. Wall (1972) Intravenous injection in man of Δ9-tetrahydro-cannabinol. Science 177:633.

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Authors
  1. Mario Perez-Reyes
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  2. Jane Simmons
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  3. Delores Brine
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  4. Gary I. Kimmel
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  5. Kenneth H. Davis
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  6. Monroe E. Wall
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Editor information

Editors and Affiliations

  1. College of Physicians & Surgeons of Columbia University, 630 West 168th Street, 10032, New York, New York, USA

    Gabriel G. Nahas M.D., Ph.D. (Research Professor of Anesthesiology) (Research Professor of Anesthesiology)

  2. University of Oxford, Oxford, England

    William D. M. Paton M.D., Ph.D. (Professor of Pharmacology) (Professor of Pharmacology)

  3. National Board of Health, Helsinki, 53, Finland

    Juhana E. Idänpään-Heikkilä M.D., D.M.Sc. (Docent, Chief Medical Officer for Pharmacology) (Docent, Chief Medical Officer for Pharmacology)

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© 1976 Springer-Verlag New York Inc.

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Perez-Reyes, M., Simmons, J., Brine, D., Kimmel, G.I., Davis, K.H., Wall, M.E. (1976). Rate of Penetration of Δ9-Tetrahydrocannabinol and 11-Hydroxy-Δ9-Tetrahydrocannabinol to the Brain of Mice. In: Nahas, G.G., Paton, W.D.M., Idänpään-Heikkilä, J.E. (eds) Marihuana. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-51624-5_15

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  • DOI: https://doi.org/10.1007/978-3-642-51624-5_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-51626-9

  • Online ISBN: 978-3-642-51624-5

  • eBook Packages: Springer Book Archive