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Marihuana pp 179-185 | Cite as

Rate of Penetration of Δ9-Tetrahydrocannabinol and 11-Hydroxy-Δ9-Tetrahydrocannabinol to the Brain of Mice

  • Mario Perez-Reyes
  • Jane Simmons
  • Delores Brine
  • Gary I. Kimmel
  • Kenneth H. Davis
  • Monroe E. Wall

Abstract

During investigations designed to study the clinical pharmacology and metabolism of cannabinoids, tritium-labeled Δ9-tetra-hydrocannabinol (Δ9-THC) and 11-OH-Δ9-THC were intravenously infused to normal control volunteers.

Keywords

Total Radioactivity Brain Concentration Cervical Fracture Public Health Service Research Percent Ethanol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Christensen, H. D., R. I. Freudenthal, J. T. Gidley, R. Rosenfeld, G. Boegli, L. Testino, D. R. Brine, C. G. Pitt, and M. E. Wall (1971) Activity of Δ8- and Δ9-tetrahydrocannabinol and related compounds in the mouse. Science 172:165.PubMedCrossRefGoogle Scholar
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    Perez-Reyes, M., M. C. Timmons, K. H. Davis, and M. E. Wall (1973) A comparison of the pharmacological activity in man of intravenously administered Δ9-tetrahydrocannabinol, cannabinol and cannabidiol. Experientia 29:1368.PubMedCrossRefGoogle Scholar
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    Perez-Reyes, M., M. C. Timmons, M. A. Lipton, H. D. Christensen, K. H. Davis, and M. E. Wall (1973) A comparison of the pharmacological activity of Δ9-tetrahydrocannabinol and its monohydroxyl-ated metabolites in man. Experientia 29:1009.PubMedCrossRefGoogle Scholar
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    Perez-Reyes, M., M. C. Timmons, M. A. Lipton, K. H. Davis, and M. E. Wall (1972) Intravenous injection in man of Δ9-tetrahydro-cannabinol. Science 177:633.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1976

Authors and Affiliations

  • Mario Perez-Reyes
  • Jane Simmons
  • Delores Brine
  • Gary I. Kimmel
  • Kenneth H. Davis
  • Monroe E. Wall

There are no affiliations available

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