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Regulation of Regulatory T Cells

  • M. C. Brunner
  • D. Caput
  • M. R. Helbert
  • N. A. Mitchison
  • K. Simon
  • J. Sieper
  • P. Wu
Conference paper

Abstract

This introductory paper reviews new ideas concerning regulatory T cells, in the fields of hyperreactivity, cytokine balance, and desequestration of self-antigens. It also summarises an older and more troubled theme in network research, the influence on these cells of IgV regions.

Keywords

Reactive Arthritis Yersinia Enterocolitica Heavy Chain Gene Lepromatous Leprosy Lyme Arthritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bell EB, Sparshot SM (1990) Interconversion of CD45R subsets of CD4 T cells in vivo. Nature 348: 163–165.PubMedCrossRefGoogle Scholar
  2. Lightstone EB, Marvel J, Mitchison NA (1992) Memory in helper T cells revealed in vivo by alloimmunizations in combination with Thyl antigen. Eur J Immunol 22:115–122.PubMedCrossRefGoogle Scholar
  3. M.R. Helbert, J. L’Age-Stehr and N.A. Mitchison (1992) Consequences of HIV mediated damage to the antigen presenting system. AIDS, submitted.Google Scholar
  4. Parronchi P, De Carli M, Manetti R, Simonelli C, Piccinni MP, Macchia D, Maggi E, Del Prete G, Ricci M, Romagnani S (1992) Aberrant Interleukin (Il)-4 and 11–5 production in vitro by Cd4+ helper t cells from atopic subjects. Eur J Immunol 22: 1615–1620PubMedCrossRefGoogle Scholar
  5. Kay AB, Sun Ying, Varney V, Gaga M, Durham SR, Moqbel R, Wardlaw AJ, Hamid Q (1991) Messenger RNA expression of the cytokine gene cluster, Interleukin 3 (Il-3), Il-4, Il-5 and Granulocyte / Macrophage Colony-Stimulating Factor in allergen-induced late-phase cutaneous reactions in atopic subjects. J Exp Med 173: 775–778PubMedCrossRefGoogle Scholar
  6. Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom B, Modlin RL (1991) Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254: 277–279PubMedCrossRefGoogle Scholar
  7. Salgame P, Abrams JS, Clayberger C, Goldstein H, Convit J, Modlin RL, Bloom B (1991) Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254: 279–282PubMedCrossRefGoogle Scholar
  8. Yssel H, Shanafelt MC, Soderberg C, Schneider P, Anzola J, Peltz G (1991) Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme Arthritis. J Exp Med 174: 593–601PubMedCrossRefGoogle Scholar
  9. Lahesmaa R, Yssel H, Batsford S, Luukainen R, Möttönen T, Steinman L, Peltz G (1992) Yersinia enterocolitica activates a T helper type 1-like T cell subset in reactive arthritis. J Immunol 148: 3079–3085PubMedGoogle Scholar
  10. Simon K, Sieper J, Wu P, Scipelt E, Braun J (1992) Unpublished results.Google Scholar
  11. Überla K, Platzer C, Diamantstein T, Blankenstein T (1991) Generation of competitor DNA fragments for quantitative PCR. PCR Meth Appl 1:136–141CrossRefGoogle Scholar
  12. Eichmann K, Rajewski K (1975) Induction of T and B cell immunity by anti-idiotypic antibody. Eur J Immunol 5:661–666PubMedCrossRefGoogle Scholar
  13. Weinberger JZ, Germain RN, Ju ST, Greene MI, Benacerraf B, Dorf ME (1979) Hapten-specific T-cell responses to 4-hydroxy-3-nitrophenyl acetyl. II. Demonstration of idiotypic determinants on suppressor T cells. J Exp Med 150:761–776PubMedCrossRefGoogle Scholar
  14. Eardley DD, Shen FW, Cantor H, Gershon RK (1979) Genetic control of immunoregulatory circuits. Genes linked to the Ig locus govern communication between regulatory T-cell sets. J Exp Med 150:44–50PubMedCrossRefGoogle Scholar
  15. Sherman L (1982) Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes. J Exp Med 156:294–299PubMedCrossRefGoogle Scholar
  16. Martinez A C, Pereira P, Bernabe R, Bandeira A, Larsson E-L, Cazenave P-A, Coutinho A (1984) Internal complementaries in the immune system: regulation of the expression of helper T-cell idiotypes. Proc Natl Acad Sci USA 81:4520–4523PubMedCrossRefGoogle Scholar
  17. Mitchison NA (1989) Is genes in the mouse. Progr. in Immunol. 7:845–852CrossRefGoogle Scholar
  18. Weaver D, Reis MH, Albanese C, Costantini F, Baltimore D, Imanishi-Kari T (1986) Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged mu heavy chain gene. Cell 45: 247–259PubMedCrossRefGoogle Scholar
  19. Lin, R-H., Mamula, M.J., Hardin, J.A., Janeway, C.A. (1991) Induction of autoreactive B cells allows priming of autoreactive T cells. J Exp Med 173:1433–1439PubMedCrossRefGoogle Scholar
  20. Lehmann PV, Forsthuber T, Miller A, Sercarz EE (1992) Spreading of T-cell autoimmunity to cryptic determinants by an autoantigen. Nature 358:155–157PubMedCrossRefGoogle Scholar
  21. Mitchison NA (1990) Unique features of the immune system: their logical ordering and likely evolution. Burger MM, Sordat B, Zinkernagel RM (eds): Cell to Cell Interaction. Basel, Karger, pp 201–214Google Scholar
  22. Cunningham DS, Fulgham DL, Rayl DL, Hansen KA, Alexander NJ (1991) Antisperm antibodies to sperm surface antigens in women with genital tract infection. Am J Obstet Gynecol 164:791–796PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • M. C. Brunner
    • 1
  • D. Caput
    • 2
  • M. R. Helbert
    • 1
  • N. A. Mitchison
    • 1
  • K. Simon
    • 1
  • J. Sieper
    • 1
  • P. Wu
    • 1
  1. 1.Robert Koch InstitutDeutsches Rheumaforschungszentrum BerlinBerlinGermany
  2. 2.Laboratoire de Biologie MoléculaireSanofi Elf BioRecherchesLabégeFrance

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