Mapping the Golgi Retention Signal in the Cytoplasmic Tail of the Uukuniemi Virus G1 Glycoprotein

  • Agneta M. Andersson
  • Ralf F. Pettersson
Conference paper
Part of the NATO ASI Series book series (volume 106)


The majority of newly synthezised secretory and membrane proteins are transported along the secretory pathway from the endoplasmic reticulum (ER) to the plasma-membrane (PM), where they are secreted or remain inserted into the membrane. A minority of the transported proteins contain sorting or retention signals which instead direct them to or retain them at specific sites within the cell.


Green Fluorescent Protein Cytoplasmic Tail Retention Signal Golgi Membrane Spike Protein 
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  1. Andersson AM, Melin L., Persson R, Raschperger E, Wikström L. and Pettersson RF (1997a) Processing and membrane topology of the spike proteins G1 and G2 of Uukuniemi virus. J. Virol. 71: 218–225PubMedGoogle Scholar
  2. Andersson AM, Melin L., Bean A and Pettersson RF (1997b) A retention signal necessary and sufficient for Golgi localization maps to the cytoplasmic tail of a Bunyaviridae (Uukuniemi virus) membrane glycoprotein. J. Virol. 71: 4717–4727PubMedGoogle Scholar
  3. Melin L., Persson R, Andersson A, Bergström A, Rönnholm R and Pettersson RF (1995) The membrane glycoprotein G1 of Uukuniemi virus contains a signal for localization to the Golgi complex. Virus Res. 36: 49–66PubMedCrossRefGoogle Scholar
  4. Munro S (1991) Sequences within and adjacent to the transmembrane segment of α-2,6-sialyltransferase specify Golgi retention. EMBO J. 10: 3577–3588PubMedGoogle Scholar
  5. Munro S (1995) An investigation of the role of the transmembrane domains in Golgi protein retention. EMBO J. 14: 4695–4704PubMedGoogle Scholar
  6. Nilsson T, Hoe MH, Slusarewicz P, Rabouille C., Watson R, Hunte F, Watzele G, Berger EG and Warren G (1994) Kin recognition between medial Golgi enzymes in HeLa cells. EMBO J. 13: 562–574PubMedGoogle Scholar
  7. Nilsson T, Rabouille C., Hui N, Watson R and Warren G (1996) The role of the membrane-spanning domain and stalk region of N-acetylglu cosaminyltransferase I in retention, kin recognition and structural maintenance of the Golgi apparatus in HeLa cells. J. Cell Sci. 109: 1975–1989PubMedGoogle Scholar
  8. Persson R and Pettersson RF (1991) Formation and intracellular transport of a heterodimeric viral spike protein complex. J. Cell biol. 112: 257–266.PubMedCrossRefGoogle Scholar
  9. Pettersson RF (1991) Protein localization and virus assembly at intracellular membranes, p. 67–98. In RW Compans (ed.), Protein traffic in eucaryotic cells. Springer-Verlag, Berlin Heidelberg, Germany.CrossRefGoogle Scholar
  10. Pettersson RF and Melin L. (1996) Synthesis, assembly and intracellular transport of Bunyaviridae membrane proteins, p. 159–188. In RM Eliott (ed.), The Bunyaviridae. Plenum Press, New York, N.Y.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Agneta M. Andersson
    • 1
  • Ralf F. Pettersson
    • 1
  1. 1.Ludwig Institute for Cancer ResearchStockholmSweden

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