Abstract
Since the introduction of thiazide diuretics into the long-term treatment of hypertension, a number of metabolic disorders have become known, the most frequently encountered and the most important of which is hypokalaemia (Table 1) (1–46, 48–110).
No common biochemical or biophysical denominator for these effects has yet been found. We have seen two cases of hypochloraemic tetany, in both of which the plasma calcium level was normal. In the first case, tetanic episodes occurred during treatment with 100 mg. hydroflumethiazide; potassium fell to 2.15 mEq./l. and the chloride concentration came down to 82 mEq./l. In the other case, a hypochloraemia of 84.5 mEq./l. developed after intravenous administration of 100 mg. ethacrynic acid, and the patient became tetanic; all other serum electrolytes remained unaffected.
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Hartmann, F., Heimsoth, V. (1966). Disturbances in carbohydrate and uric-acid metabolism during diuretic treatment. In: Gross, F. (eds) Antihypertensive Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50238-5_27
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DOI: https://doi.org/10.1007/978-3-642-50238-5_27
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