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Some biochemical aspects of treatment and diagnosis of hypertension

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Antihypertensive Therapy

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Abstract

The catecholamine hormone norepinephrine (N.E.) lies at the center of most recent developments in the chemotherapy of hypertension. Drugs such as reserpine, guanethidine, a-methyldopa, and the monamine-oxidase (M.A.O.) inhibitors, by varying mechanisms, interfere with processes which govern the availability of this sympathetic nerve transmitter to receptor sites (e.g. blood vessels) and thereby lower the blood pressure. Although it has not been shown that N.E. plays a primary role in the pathogenesis of essential hypertension, this hormone and its N-methylated derivative, epinephrine, are responsible for the occurrence of the hypertensive syndrome in patients with pheochromocytoma. Chemical assay of these catecholamines and their major metabolites in urine provides the most definitive means of diagnosing this condition.

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Authors
  1. A. Sjoerdsma
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F. Gross

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© 1966 Springer-Verlag · Berlin · Heidelberg

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Sjoerdsma, A. (1966). Some biochemical aspects of treatment and diagnosis of hypertension. In: Gross, F. (eds) Antihypertensive Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50238-5_18

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  • DOI: https://doi.org/10.1007/978-3-642-50238-5_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-50240-8

  • Online ISBN: 978-3-642-50238-5

  • eBook Packages: Springer Book Archive

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