Skip to main content
SpringerLink
Log in

Simultane Bestimmung von Säure und Puffer im Magensaft

  • Conference paper
Pharmakodynamische Modelle für die Arzneimittelentwicklung

Part of the book series: Konzepte in der Humanpharmakologie ((KONZHUMAN))

  • 77 Accesses

Zusammenfassung

Vorgestellt wird die Entwicklung einer einfachen Methode zur gleichzeitigen Bestimmung von Pufferkapazität und Säuregehalt im menschlichen Magensaft. In einer humanpharmakologischen Studie wird die Anwendung der Methode bei der pharmakologischen Profilierung eines PGI2 -Derivates im Vergleich mit Cimetidin, Carbenoxolon und der pentagastrinsümulierten Magenschleimhaut als Kontrollbehandlung demonstriert.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Andre C, Bruhiere J, Vague M, Lambert R (1973). Bicarbonate secretion in human stomach. Acta Hepato-Gastroenterologica 20, 62–69

    PubMed  CAS  Google Scholar 

  2. Crampton JR, Gibbons LC, Rees WDW (1987). Effect of luminal pH on output of bicarbonate and PGE2, by normal human stomach. Gut 28, 1291–1295

    Article  PubMed  CAS  Google Scholar 

  3. Elder JB, Hearn AR (1980). Intragastric pCO2 in man and calculated gastric bicarbonate concentrations: effect of cabenoxolone sodium. Scand J Gastroenterology 15 (Suppl 65)+ 19–25

    Google Scholar 

  4. Feldman M (1985). Gastric H and HCO3 secretion in response to sham feeding in humans. Am J Physiology 248, G188-G191

    CAS  Google Scholar 

  5. Forsell H, Preshaw R, Olbe L (1984). Gastric secretion of bicarbonate in man determined with a perfusion technique; in Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, A Allen (ed.). Raven Press, New York, pp. 125–127

    Google Scholar 

  6. Konturek SJ, Kwielien N, Obtulowicz W, Thor P (1987). Vagal cholinergic control of gastric alkaline secretion in normal subjects and duodenal ulcer patients. Gut 28, 739–744

    Article  PubMed  CAS  Google Scholar 

  7. Makhlouf GM, McManus JPA, Card WJ (1966). A quantitative statement of the two component hypothesis of gastric secretion. Gastroenterology 51, 149–171

    PubMed  CAS  Google Scholar 

  8. Okosdinossian E, EL Munshid HA (1977). Composition of alkaline component of human gastric juice: effect of swallowed saliva and duodeno-gastric reflux. Scand J Gastroenterology 12, 945–950

    Article  CAS  Google Scholar 

  9. Sjövall H, Forsell H, Olbe L (1989). Simultaneous measurement of gastric acid and bicarbonate secretion in man. Scand J Gastroenterology 24, 1163–1171

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Humanpharmakologie, Forschungslaboratorien, Schering AG, Berlin, Deutschland

    A. Fuhrmeister & W. Seifert

Authors
  1. A. Fuhrmeister
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Seifert
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Humanpharmakologie, Schering AG, Müllerstraße 170-178, W-1000, Berlin 65, Germany

    Lothar Lange  & Wolf Seifert  & 

  2. LAB, Gesellschaft für pharmakologische Untersuchungen mbH & Co., Postfach 1680, W-7910, Neu-Ulm, Germany

    Halvor Jaeger  & Ingrid Klingmann  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Fuhrmeister, A., Seifert, W. (1993). Simultane Bestimmung von Säure und Puffer im Magensaft. In: Lange, L., Seifert, W., Jaeger, H., Klingmann, I. (eds) Pharmakodynamische Modelle für die Arzneimittelentwicklung. Konzepte in der Humanpharmakologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50229-3_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-50229-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-50230-9

  • Online ISBN: 978-3-642-50229-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation