Computer Aided Protein Design: Three Dimensional Model Building of the Saruplase Structure

  • W. Straßburger
  • W. Winter
  • G. J. Steffens
  • W. A. Günzler
  • L. Flohé
Conference paper


Modelling studies of the three-dimensional structures of the saruplase-domains are presented. The model of the N-terminal EGF-like domain highlights amino acids residues which might be involved in interactions with saruplase specific receptors. The distribution of charged residues on the surface of the kringle-model is different from other kringle- structures. The model structure of the catalytic serine-protease domain points to surface loops, which surround the active site and may participate in interactions with plasminogen. Starting from the structures of the isolated domains a model for the entire enzyme is constructed which is compatible with experimental results.


Molecular Dynamic Simulation Charge Amino Acid Similar Amino Acid Protease Domain Surface Loop 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • W. Straßburger
    • 1
  • W. Winter
    • 1
  • G. J. Steffens
    • 1
  • W. A. Günzler
    • 1
  • L. Flohé
    • 1
  1. 1.Center of ResearchGrünenthal GmbHAachenGermany

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