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Sjögren’s Syndrome pp 203–217Cite as

Rheumatoid Factor in Sjögren’s Syndrome

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Abstract

Rheumatoid factors (RF) are defined by their ability to bind to the Fc portion of IgG molecules. This activity in the sera of rheumatoid arthritis (RA) patients was first noted as an atypical reaction during agglutination tests to detect antibodies to microbial antigens (Rose et al. 1948; Waaler 1940). The antibody nature of RF and its binding to different subclasses of IgG has been the subject of extensive investigations [reviewed in Fong et al. 1984]. As more sensitive tests for RF became available (Carson et al. 1977; Pope & McDuffy 1981; Koopman & Schrohenloher 1980), the presence of this antibody in other autoimmune conditions including Sjögren’s syndrome was recognized. Further, certain infectious diseases (Brouet et al. 1974) and B cell malignancies (Kunkel et al. 1961; Kunkel et al. 1973) are associated with RF. Recently, it has been recognized that this “autoantibody” may be synthesized in association with secondary immune responses in normal humans and in animals (Welch et al. 1983; Coulie & Van Snick 1983; Nemazee & Sato 1983). These results have suggested that RF plays a physiologic role in normal immune responses (Grabar 1983; Guilbert et al. 1983) and that persistent stimulation of these cells may lead to their neoplastic transformation (Berard et al. 1981).

Supported by grants AM 33294 and AM 33983 from the National Institutes of Health and by grants from the Price Family Charitable Foundation and the Kieckhefen Foundation. This is publication number 4383BCR from the Research Foundation of Scripps Clinic.

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Abbreviations

SS:

Sjögren’s syndrome

WM:

Waldenstrom’s macroglobulinemia

RF:

rheumatoid factor

CRI:

cross reactive idiotype

RA:

rheumatoid arthritis

SLE:

systemic lupus erythematosus

CDR:

complementarity determining region

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Authors
  1. S. Fong
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  2. P. Chen
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  3. D. A. Carson
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  4. R. I. Fox
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Editor information

Editors and Affiliations

  1. Department of Medical, Division of Clinical Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78284-7874, San Antonio, TX, USA

    Norman Talal M.D.

  2. Department of Internal Medicine, University of Ioannina Medical School, 45332, Ioannina, Greece

    Haralampos M. Moutsopoulos M.D., F.A.C.P.

  3. Rehabilitation Center, Lutheran Medical Center, 7760 West 38th Avenue 290, 80033, Wheat Ridge, CO, USA

    Stuart S. Kassan M.D., F.A.C.P.

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© 1987 Springer-Verlag Berlin Heidelberg

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Fong, S., Chen, P., Carson, D.A., Fox, R.I. (1987). Rheumatoid Factor in Sjögren’s Syndrome. In: Talal, N., Moutsopoulos, H.M., Kassan, S.S. (eds) Sjögren’s Syndrome. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50118-0_20

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  • DOI: https://doi.org/10.1007/978-3-642-50118-0_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-50120-3

  • Online ISBN: 978-3-642-50118-0

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