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Lymphoid Malignancy and Monoclonal Proteins

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Sjögren’s Syndrome

Abstract

Bunim and Talal (1963) first reported an increased incidence of non-Hodgkin’s lymphoma in patients with SS over two decades ago and suggested that the chronic antigenic stimulation triggered a malignant transformation event. There were three cases of lymphoma and one case of Waldenstrom’s macroglobulinemia which developed in 58 patients with SS. Since then, several case reports have suggested an association between SS and frank lymphoma (Talal and Bunim 1964; Hornbaker et al. 1966; Talal et al. 1967) or Waldenstrom’s macroglobulinemia (Anderson and Talai 1972; Whitehouse et al. 1967) as well as an aggressive lymphoid infiltrative disorder termed “pseudolymphoma” (Talal et al. 1967). There are now over one hundred examples of this association in the medical literature (Kassan et al. 1978; Schmid et al. 1982).

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Authors
  1. A. G. Tzioufas
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  2. H. M. Moutsopoulos
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  3. N. Talal
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Editor information

Editors and Affiliations

  1. Department of Medical, Division of Clinical Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78284-7874, San Antonio, TX, USA

    Norman Talal M.D.

  2. Department of Internal Medicine, University of Ioannina Medical School, 45332, Ioannina, Greece

    Haralampos M. Moutsopoulos M.D., F.A.C.P.

  3. Rehabilitation Center, Lutheran Medical Center, 7760 West 38th Avenue 290, 80033, Wheat Ridge, CO, USA

    Stuart S. Kassan M.D., F.A.C.P.

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© 1987 Springer-Verlag Berlin Heidelberg

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Tzioufas, A.G., Moutsopoulos, H.M., Talal, N. (1987). Lymphoid Malignancy and Monoclonal Proteins. In: Talal, N., Moutsopoulos, H.M., Kassan, S.S. (eds) Sjögren’s Syndrome. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50118-0_13

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  • DOI: https://doi.org/10.1007/978-3-642-50118-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-50120-3

  • Online ISBN: 978-3-642-50118-0

  • eBook Packages: Springer Book Archive

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