Abstract
Although it has been the subject of continued investigation by-several laboratories over the past decade, the macrophage resistance gene (Lsh/lty/Bcg), located between Idh-1 and Pep-3 on mouse chromosome 1, enters its second decade without having been characterized either at the level of a protein gene product or at the mRNA/DNA level. While the different laboratories have all at one time or another recognised the potential importance of the gene as a natural resistance mechanism operating against a broad range of phylogenetically distinct macrophage pathogens, recent observations that a cluster of linked genes including Idh-1 (Narahara et al., 1985), Myl-1 (Robert et al., 1985), fibronectin (Jhanwar et al., 1986), villin (Rousseau-Merck et al., 1988), collagen (COL3A1, COL5A2, COL6A3) (Weil et al., 1988), glucagon (Schroeder et al., 1984), elastin (Emanuel et al., 1985), acetylcholine receptor (Heidmann et al., 1986) and gamma-crystallin (Len-1) (Shiloh et al., 1986) have been conserved onto the long arm of human chromosome 2 (around 2q31-qter) has refuelled interest in identification of an Lsh gene homologue in man.
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© 1988 Springer-Verlag Berlin · Heidelberg
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Blackwell, J.M., Toole, S., King, M., Dawda, P., Roach, T.I.A., Cooper, A. (1988). Analysis of Lsh Gene Expression in Congenic B10.L-Lsh’ Mice. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_45
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DOI: https://doi.org/10.1007/978-3-642-50059-6_45
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