Abstract
The mechanism by which fractionated-x-irradiation (FXI) induces leukemia has been much debated. Kaplan and Brown (1952) first showed that fractionated doses of x-irradiation can cause leukemia in mice. Gross (1958) , and Lieberman and Kaplan (1959) , subsequently reported the transfer of neoplasia by radiation-induced leukemia virus, RadLV, obtained from FXI-induced leukemias. However, despite the identification of type-C ENA particles in FXI-induced leukemias and the demonstration that such particles can, when injected into young mice, cause lymphomas, several investigators have taken exception with the concept of a viral etiology for FXI-induced leukemia (Ihle et al., 1976, 1976a, 1978; Haran-Ghera 1977; Pazmino et al., 1978; Mayer and Dorsch-Hasler 1982) . The etiological mechanism(s) of this disease however remains unclear.
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References
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© 1988 Springer-Verlag Berlin · Heidelberg
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Amari, N.M.B., Scandalis, S., Zhang, D., Pampeno, C.L., Arant, S., Meruelo, D. (1988). Reverse Genetics Approaches for Cloning RIL-1, a Major Locus Involved in Susceptibility to Leukemia. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_39
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DOI: https://doi.org/10.1007/978-3-642-50059-6_39
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