Genetic Analysis of BALB/cJ Subline Resistance to Actively Induced Experimental Allergic Orchitis (EAO) and Experimental Allergic Encephalomyelitis (EAE)

  • C. Teuscher
  • E. P. Blankenhorn
  • W. F. Hickey
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 137)


EAO and EAE are two organ-spec ific autoimmune diseases which can be readily induced in genetically susceptible’strains of mice (Teuscher et al. 1985a; Arnon 1981). Murine EAO is manifest as inflammation of the testes (orchitis), aspermatogensis, epididymitis, and vasitis (Kohno et al. 1983), whereas acute EAE is manifest clinically by varying degrees of paraparesis and paralysis, accompanied by lymphocytic and mononuclear cell infiltration of the central nervous system (CNS) (Arnon 1981). It was previously demonstrated that significant differences in susceptibility to actively induced EAO and EAE exist among various sublines of BALB/c mice (Teuscher et al. 1985b; Teuscher et al. 1987a; Munoz and Mackay 1984; Hickey et al. 1986). Of the 13 substrains studied, BALB/cJ mice were consistantly resistant to the induction of both diseases. The BALB/cJ substain is unique within the BALB/c family since it differs from other BALB/c substrains by several characteristic phenotypes (Potter 1985). One such phenotype, which may be relevant to disease susceptibility, is the elevated levels of serum alpha-fetoprotem (AFP) in adult BALB/cJ mice. It has been suggested that AFP may be immunosuppressive and that it is capable of suppressing EAE (Murgita and Tomasi 1975; Abaramsky et al. 1982; Brenner et al. 1985), although these findings are not conclusive (Fujinami et al. 1976).


Experimental Allergic Encephalomyelitis Mononuclear Cell Infiltration Mouse Central Nervous System Reprod Immunol Backcross Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abaramsky O, Brenner T, Mizrachi R, Soffer, D (1982) Alpha-fetoprotein suppresses experimental allergic encephalomyelitis. J Neuroimmunol 2, 1–7CrossRefGoogle Scholar
  2. Adekunle AO, Hickey WF, Smith SM, Tung KSK, Teuscher, C (1987) Experimental allergic orchitis in mice: IV. Preliminary characterization of the major murine testis specific aspermatogenic autoantigen(s). J Reprod Immunol 12, 49–62PubMedCrossRefGoogle Scholar
  3. Arnon, R (1981) Experimental allergic encephalomyelitis-susceptib£lity and suppression. Immunol Rev 55, 5–30PubMedCrossRefGoogle Scholar
  4. Blankenhorn EP, Wax JS, Matthai R, Potter, M (1985) Genetic analysis of alpha-fetoprotein levels in BALB/c sublines. Curr Top Microbiol Immunol 122, 53–57PubMedCrossRefGoogle Scholar
  5. Brenner T, Evron S, Soffer D, Abramsky O, (1985) Treatment of experimental allergic encephalomyelitis in rabbits with alpha-fetoprotein. Israel J Med Sci 21, 945–949PubMedGoogle Scholar
  6. Fujinami RS, Paterson PY, Parmely MJ, Thompson JS, Goeken NE (1976) Lack of suppressive effects of alpha-fetoprotein on development of experimental allergic encephalomyelitis in rats. Nature (London) 264, 782–783CrossRefGoogle Scholar
  7. Hickey WF, Kirby WM, Teuscher C (1986) BALB/c substrain differences in susceptibility to experimental allergic encephalomyelitis (EAE). Ann NY Acad Sci 475, 331–333CrossRefGoogle Scholar
  8. Kohno S, Munoz, JJ, Williams TM, Teuscher C, Bernard CCA, Tung KSK (1983) Immunopathology of murine experimental allergic orchitis. J Immunol 130, 2675–2682PubMedGoogle Scholar
  9. Lando Z, Teitlbaum D, Arnon R (1979) Genetic control of susceptibility to experimental allergic encephalomyelitis in mice. Immunogenetics 9, 435–442CrossRefGoogle Scholar
  10. Munoz JJ, Mackay IR (1984) Production of experimental allergic encephalomyelitis with the aid of pertussigen in mouse strains considered genetically resistant. J Neuroimmunol 7, 91–96PubMedCrossRefGoogle Scholar
  11. Murgita RA, Tomasi, TB (1975) Suppression of the immune response by fetoprotein. J Exp Med 141, 440–452CrossRefGoogle Scholar
  12. Olsson M, Lindahl G, Ruoslahti E (1977) Genetic control of alpha-fetoprotein synthesis in the mouse. J Exp Med 145, 819–827PubMedCrossRefGoogle Scholar
  13. Potter M (Ed) (1985) The BALB/c Mouse. Curr Top Microbiol Immunol 122Google Scholar
  14. Teuscher C, Smith SM, Goldberg EH, Shearer GM, Tung KSK (1985a) Experimental allergic orchitis m mice: I. Genetic control of susceptibility and resistance to induction of autoimmune orchitis. Immunogenetics 22, 323–333PubMedCrossRefGoogle Scholar
  15. Teuscher C, Potter M, Tung KSK (1985b) Differential susceptibility to experimental autoimmune orchitis in BALB/c substrains. Curr Top Microbiol Immunol 122, 181–188PubMedCrossRefGoogle Scholar
  16. Teuscher C, Smith SM, Tung KSK (1987a) Experimental allergic orchitis in mice: III. Differential susceptibility and resistance among BALB/c sublines. J Reprod Immunol 10, 219–230PubMedCrossRefGoogle Scholar
  17. Teuscher C, Blankenhorn EP, Hickey WF (1987b) Differential susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis among BALB/c substrains. Cell Immunol (In press)Google Scholar
  18. Tung, KSK, Teuscher C, Smith S, Ellis L, Dufau ML (1985) Factors that regulate the development of testicular autoimmune disease. Ann NY Acad Sei 438, 171–188CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • C. Teuscher
  • E. P. Blankenhorn
  • W. F. Hickey

There are no affiliations available

Personalised recommendations