Genetic Analysis of BALB/cJ Subline Resistance to Actively Induced Experimental Allergic Orchitis (EAO) and Experimental Allergic Encephalomyelitis (EAE)

  • C. Teuscher
  • E. P. Blankenhorn
  • W. F. Hickey
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 137)

Abstract

EAO and EAE are two organ-spec ific autoimmune diseases which can be readily induced in genetically susceptible’strains of mice (Teuscher et al. 1985a; Arnon 1981). Murine EAO is manifest as inflammation of the testes (orchitis), aspermatogensis, epididymitis, and vasitis (Kohno et al. 1983), whereas acute EAE is manifest clinically by varying degrees of paraparesis and paralysis, accompanied by lymphocytic and mononuclear cell infiltration of the central nervous system (CNS) (Arnon 1981). It was previously demonstrated that significant differences in susceptibility to actively induced EAO and EAE exist among various sublines of BALB/c mice (Teuscher et al. 1985b; Teuscher et al. 1987a; Munoz and Mackay 1984; Hickey et al. 1986). Of the 13 substrains studied, BALB/cJ mice were consistantly resistant to the induction of both diseases. The BALB/cJ substain is unique within the BALB/c family since it differs from other BALB/c substrains by several characteristic phenotypes (Potter 1985). One such phenotype, which may be relevant to disease susceptibility, is the elevated levels of serum alpha-fetoprotem (AFP) in adult BALB/cJ mice. It has been suggested that AFP may be immunosuppressive and that it is capable of suppressing EAE (Murgita and Tomasi 1975; Abaramsky et al. 1982; Brenner et al. 1985), although these findings are not conclusive (Fujinami et al. 1976).

Keywords

Arthritis Albumin Cage Tyrosine Tuberculosis 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • C. Teuscher
  • E. P. Blankenhorn
  • W. F. Hickey

There are no affiliations available

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