Abstract
In eutherian females one of the two sex chromosomes is inactive (Lyon, 1961; Russell, 1961) . The inactive status is established relatively early during embryogenesis and is somatically heritable within a cell lineage throughout development (see Chapman, 1987) . The inactivation event is generally random with respect to the parental origin of an X chromosome such that equal numbers of cells expressing the paternal (XP) - and maternal (Xm) chromosome can be seen as a mosaic mixture in adult tissues using a variety of direct and indirect measures of X chromosome gene function (see reviews by West, 1982; Gartler and Riggs, 1983; Chapman, 1987)
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© 1988 Springer-Verlag Berlin · Heidelberg
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Chapman, V.M., Grant, S.G., Benz, R.A., Miller, D.R., Stephenson, D.A. (1988). X-Chromosome Linked Mutations Affecting Mosaic Expression of the Mouse X Chromosome. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_27
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DOI: https://doi.org/10.1007/978-3-642-50059-6_27
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