The Immunobiology of the T Cell Response to Mls Locus Disparate Stimulator Cells

  • C. A. JanewayJr.
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 137)


The Mls locus described by Festenstein (1973) is a murine locus at which polymorphism leads to unidirectional stimulation in mixed lymphocyte reactions (MLR). Initially, four alleles were described, but recent analysis has shown that these original assignments probably reflect two segregating loci, each with two alleles (Abe et al, 1987). In describing the immunobiology of the T cell response to Mls locus disparities, I will consider only those mapping to chromosome 1, originally termed Mls a and Mls b for the stimulating and responding alleles respectively. Disparities at this locus stimulate the most potent and reproducible responses in primary MLR, and are consequently the most interesting for immunobiological analysis.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1988

Authors and Affiliations

  • C. A. JanewayJr.
    • 1
  1. 1.Department of Pathology and Section of Immunobiology, Howard Hughes Medical InstituteYale University School of MedicineNew HavenUSA

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