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Introduction

  • Chapter
Gel Chromatography

Abstract

Next to chemical composition, size and weight are the most significant properties of a molecule. Molecular weight is frequently the decisive parameter that distinguishes molecules. Differences in molecular size play a role in all conventional physical separation methods. The higher homologues of a series usually show higher melting and boiling points as well as lower solubility than the lower compounds of similar structure. For all practical purposes these differences overlap with other properties such as polarity or electrical charge density which determine the behavior of a substance during crystallization, distillation, extraction or most chromatographic methods of separation. Sorting by size is a very common ordering principle in the macroscopic world. At the molecular level it was applied relatively late and in only a few isolated cases. Moreover, it is naturally also true for separations based on differences in molecular weight that factors other than the difference in molecular size may play a role.

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  1. Institut für Organische Chemie, Universität Frankfurt am Main, Frankfurt am Main, Germany

    Dr. phil. nat. Helmut Determann (Privatdozent)

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  1. Dr. phil. nat. Helmut Determann
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© 1969 Springer-Verlag Berlin Heidelberg

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Determann, H. (1969). Introduction. In: Gel Chromatography. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49886-2_1

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  • DOI: https://doi.org/10.1007/978-3-642-49886-2_1

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